Table 2 Baseline characteristics of 33 patients receiving sirolimus gel for facial angiofibroma associated with tuberous sclerosis complex
Characteristics | Number | % |
|---|---|---|
Median age (range) | 25 (14–55) | |
Sex | ||
Male/Female | 17/16 | |
ECOG performance status | ||
0/1/2 | 24/8/1 | |
Major features | ||
≥ 3 Hypomelanotic macules | 20 | 61 |
≥ 2 Ungual fibromas | 18 | 55 |
Shagreen patch | 17 | 52 |
Multiple retinal hamartomas | 6 | 18 |
Cortical dysplasias | 25 | 76 |
Subependymal nodules | 19 | 58 |
Subependymal giant cell astrocytoma | 5 | 15 |
Cardiac rhabdomyoma | 4 | 12 |
Lung lymphangioleiomyomatosis | 6 | 18 |
≥ 2 Renal angiomyolipomas | 31 | 94 |
Minor features | ||
≥ 3 Dental enamel pits | 10 | 30 |
≥ 2 Intraoral fibromas | 6 | 18 |
Retinal achromic patch | 5 | 15 |
Multiple renal cysts | 2 | 6 |
Nonrenal hamartomas | 1 | 3 |