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Table 2 Motor milestone (HINE-2) scores at T0 and Y1 for patients aged less than 2 years

From: Effects of nusinersen after one year of treatment in 123 children with SMA type 1 or 2: a French real-life observational study

HINE-2 scoreT0Y1P
Head control (0–2) (n = 17)1.2 / 1 (0–2)1.9 / 2 (1–2)0.008
Sitting (0–4) (n = 17)1.4 / 1 (0–4)2.8 / 3 (0–4)< 0.001
Voluntary grasp – note side (0–3) (n = 17)2.2 / 2 (0–3)2.8 / 3 (2–3)0.008
Ability to kick in supine (0–4) (n = 17)1.4 / 1 (0–4)3.2 / 4 (1–4)< 0.001
Rolling (0–3) (n = 17)0.6 / 0 (0–3)1.8 / 2 (0–3)0.001
Crawling or bottom shuffling (n = 17)0.6 / 0 (0–4)1.1 / 1 (0–4)0.008
Standing (0–3) (n = 17)0.1 / 0 (0–2)0.6 / 0 (0–3)0.016
Walking (0–3) (n = 17)0.1 / 0 (0–1)0.3 / 0 (0–2)0.25
HINE- 2 Total score (0–26) (n = 20)7 / 4 (0–23)14.5 / 14.5 (7–25)< 0.001
  1. Minimum and maximum values for each sub-score are indicated in parentheses in the first column. The values shown are average / median (range). Statistically significant differences (p < 0.05) are highlighted in bold font