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Table 2 Motor milestone (HINE-2) scores at T0 and Y1 for patients aged less than 2 years

From: Effects of nusinersen after one year of treatment in 123 children with SMA type 1 or 2: a French real-life observational study

HINE-2 score

T0

Y1

P

Head control (0–2) (n = 17)

1.2 / 1 (0–2)

1.9 / 2 (1–2)

0.008

Sitting (0–4) (n = 17)

1.4 / 1 (0–4)

2.8 / 3 (0–4)

< 0.001

Voluntary grasp – note side (0–3) (n = 17)

2.2 / 2 (0–3)

2.8 / 3 (2–3)

0.008

Ability to kick in supine (0–4) (n = 17)

1.4 / 1 (0–4)

3.2 / 4 (1–4)

< 0.001

Rolling (0–3) (n = 17)

0.6 / 0 (0–3)

1.8 / 2 (0–3)

0.001

Crawling or bottom shuffling (n = 17)

0.6 / 0 (0–4)

1.1 / 1 (0–4)

0.008

Standing (0–3) (n = 17)

0.1 / 0 (0–2)

0.6 / 0 (0–3)

0.016

Walking (0–3) (n = 17)

0.1 / 0 (0–1)

0.3 / 0 (0–2)

0.25

HINE- 2 Total score (0–26) (n = 20)

7 / 4 (0–23)

14.5 / 14.5 (7–25)

< 0.001

  1. Minimum and maximum values for each sub-score are indicated in parentheses in the first column. The values shown are average / median (range). Statistically significant differences (p < 0.05) are highlighted in bold font