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Table 3 Influencing factors on total COI

From: Costs of illness in amyotrophic lateral sclerosis (ALS): a cross-sectional survey in Germany

Variable Change in total costs, € 95% CI p-value
ALSFRS-R score (max. 48) -2333 −3584 to −1082 0.000
Permanent attendance of a caregiver necessary 22,178 2684 to 41,671 0.026
Invasive ventilation 47,803 5112 to 90,493 0.029
Wheelchair use 14,081 1388 to 26,774 0.030
Underweight 14,378 −9564 to 38,320 0.237
Classified into a care level − 6491 −27,461 to 14,479 0.541
Feeding tube use 7617 −17,849 to 33,084 0.555
Currently working − 6150 −28,304 to 16,005 0.584
n 127   
  1. This multiple linear regression model showed significant influence of the ALSFRS-R score, wheelchair use, invasive ventilation, and the necessity of permanent attendance of another caregiver on total costs. The model was adjusted for statistical outliers
  2. Abbreviations: COI cost of illness, Euro, CI confidence interval, ALSFRS-R Revised Amyotrophic Lateral Sclerosis Functional Rating Scale, n number