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Table 3 Influencing factors on total COI

From: Costs of illness in amyotrophic lateral sclerosis (ALS): a cross-sectional survey in Germany

VariableChange in total costs, €95% CIp-value
ALSFRS-R score (max. 48)-2333−3584 to −10820.000
Permanent attendance of a caregiver necessary22,1782684 to 41,6710.026
Invasive ventilation47,8035112 to 90,4930.029
Wheelchair use14,0811388 to 26,7740.030
Underweight14,378−9564 to 38,3200.237
Classified into a care level− 6491−27,461 to 14,4790.541
Feeding tube use7617−17,849 to 33,0840.555
Currently working− 6150−28,304 to 16,0050.584
  1. This multiple linear regression model showed significant influence of the ALSFRS-R score, wheelchair use, invasive ventilation, and the necessity of permanent attendance of another caregiver on total costs. The model was adjusted for statistical outliers
  2. Abbreviations: COI cost of illness, Euro, CI confidence interval, ALSFRS-R Revised Amyotrophic Lateral Sclerosis Functional Rating Scale, n number