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Table 1 Characteristics of the study sample

From: Transbronchial lung biopsy for the diagnosis of lymphangioleiomyomatosis: the severity of cystic lung destruction assessed by the modified Goddard scoring system as a predictor for establishing the diagnosis

Ā 

Total

(Nā€‰=ā€‰19)

TBLB

P value

positive

(Nā€‰=ā€‰15)

negative

(Nā€‰=ā€‰4)

Age

41 (29ā€“58)

42 (29ā€“58)

40 (37ā€“49)

0.928

mMRC score

0/1/2

2/12/5

2/10/3

0/2/2

0.219

Smoking history ā€ 

0.530

ā€ƒnever

ā€ƒex-smoker

14

5

10

5 ā€ 

4

0

Ā 

Serum VEGF-D (pg/mL)

2324.7

(457.3ā€“5932.1)

3138.8

(516.9ā€“5932.1)

2213.6

(457.3ā€“2324.7)

0.263

Extrapulmonary LAM lesions ā€”

11

8

3

0.603

Pulmonary function tests

ā€ƒVC (%pred)

101.7

(77.3ā€“126.4)

101.7

(77.3ā€“126.4)

96.8

(79.8ā€“105.4)

0.460

ā€ƒFEV1(%pred)

64.8

(37.6ā€“89.0)

62.0

(37.6ā€“89.0)

66.7

(59.3ā€“81.1)

0.539

ā€ƒFEV1/FVC (%)

73.4

(35.4ā€“103.4)

71.1

(35.4ā€“103.4)

81.8

(70.0ā€“90.3)

0.307

ā€ƒDLco (%pred)

36.3

(20.9ā€“65.9)

36.3

(26.6ā€“64.4)

38.5

(20.9ā€“65.9)

0.980

MGS

2.72

(0.92ā€“3.61)

2.72

(1.17ā€“3.61)

2.08

(0.92ā€“2.89)

0.017

  1. Values are presented as counts, median values (range)
  2. ā€  Each pack-years is 1.4, 3.5, 6, 7 and 34
  3. ā€” Extrapulmonary LAM includes lymphangioleiomyoma of the mediastinum, retroperitoneum, and pelvis
  4. Abbreviations: DLco, diffusing capacity of carbon monoxide; FEV1, forced expiratory volume in 1ā€‰s; FVC, forced vital capacity; LAM, lymphangioleiomyomatosis; MGS, modified Goddard score; mMRC, modified Medical Research Council; TBLB, transbronchial lung biopsy; VC, vital capacity; VEGF-D, vascular endothelial growth factor-D; %pred, % of the predicted volume