Fig. 3

Networks of RCTs investigating interventions to induce (left) or maintain (right) disease remission. Each circle represents an intervention (arm). The dimension of the circle is proportional to the number of patients enrolled/planned to be enrolled in that arm. Two or more interventions are connected when compared within a trial. The thickness of the connector is proportional to the number of trials planned for each comparison. List of abbreviations for treatments included in networks. ABA, Abatacept; ALE, Alemtuzumab; AZA, Azathioprine; BLI, Blisibimod; BLM, Belimumab; CCX168, Avacopan; CYC, Cyclophosphamide; DFPP + CYC, Double filtration plasmapheresis + cyclophosphamide; DMT, Discontinuation of maintenance treatment; ECU, Eculizumab; GC, Glucocorticoids; GGS, Freeze-Dried Sulfonated Human Normal Immunoglobulin; CSP, Gusperimus; IFX, IFX-1 CaCP 29; LEU, Depot leuprolide acetate; LFL, Leflunomide; MIT, Maintenance of immunosuppressive treatment; MMF, Mycophenolate mofetil; MPZ, Mepolizumab; MTX, Methotrexate; PEC, Plasma exchange; RTX, Rituximab; SOC, Standard of care