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Table 3 Overview of the assessment of depression in MRKH patients

From: Study on depressive symptoms in patients with Mayer-Rokitansky-Küster-Hauser syndrome: an analysis of 141 cases

Reference

subjects (response rate; age)

instruments

scores on depression between two groups

strengths

limitations

Heller-Boersma et al., 2009, Psychosomatics [3]

patient group: 66, mean age:27.9 ± 1.0 yrs., response rate: 20% (66/355); control group:31 healthy women, mean age: 27.8 ± 1.5 yrs.

The symptom checklist (SCL-90-R); The Rosenberg Self- Esteem Scale (RSE); The Inventory of Interpersonal Problems (IIP-32)

no significant difference

Well-matched comparison group; Widely used questionnaires;

cross-sectional design; small sample size; selection bias (Response rate: 20%)

Adds to the limited knowledge of psychological functioning in MRKH patients.

Claudia Gatti et al., 2010, THE JOURNAL OF UROLOGY [13]

patient group:40, mean age:27.8 ± 1.3 yrs., response rate: 93% (40/43); control group: 30 healthy women, mean age: 27.8 ± 1.4 yrs.

BDI (Beck Depression Index); RSES; FSFI; Cohen Test for Life Management Ability (CTLMA)

no significant difference

Well-matched comparison group; Adds to the limited knowledge

cross-sectional design; small sample size; selection bias

Liao et al., 2011, AJOG [14]

patient group: 56, mean age:21.7 (18–52 yrs), response rate:72% (56/87); control group: standardization population.

SF-12; HADS; FSFI; Multidimensional Sexuality Questionnaire (MSQ)

no significant difference

Widely used questionnaires; Adds to the limited knowledge.

cross-sectional design; normative data are from a general population.

Katharina Leithner et al., 2015, PLOS ONE [15]

patient group:10, mean age:36.7 ± 11.1 yrs., response rate: 59% (10/17); control group: 20 healthy women, mean age:25.5 ± 4.21 yrs.

FSFI; PHQ; Brief Symptom Inventory (BSI); World Health Organization Quality of Life Assessment (WHOQoL-BREF)

no significant difference

Adds to the limited knowledge.

cross-sectional design; small sample size

P.T.M. Weijenborg, et al., 2019, Human Reproduction [16]

patient group: 54, mean age:39.2 ± 13.8 yrs. response rate: 85%(54/63); control group: 79 healthy women, mean age: 36.7 ± 11.1 yrs.

SCL-90; HADS; RSES; FSFI; Female Sexual Distress Scale (FSDS); Female Genital Self-Image Scale (FGSIS); Maudsley Marital Questionnaire (MMQ)

no significant difference

Well-matched comparison group; Widely used and comprehensive questionnaires;

cross-sectional design; selection bias; small sample size;

Adds to the limited knowledge.