Lung function in Birt-Hogg-Dubé syndrome: a retrospective analysis of 96 patients

Table 4 Multivariable linear mixed model of the associations between clinical characteristics and lung function during follow-up

Variable	FEV₁ (%pred)		FVC (%pred)		TLC (%pred)		RV (%pred)		RV/TLC (%)		DLco (%pred)		DLco/V_A (%pred)
Variable	β	p	β	p	β	p	β	p	β	p	β	p	β	p
Time
year 1	2.23	0.122	3.22	0.045	1.45	0.511	−5.80	0.402	−1.59	0.265	1.31	0.629	−2.04	0.421
year 2	−1.15	0.476	0.14	0.937	−0.47	0.862	−12.95	0.111	−3.18	0.055	−0.97	0.745	−4.15	0.127
year 3	0.92	0.598	2.37	0.234	5.97	0.043	−10.7	0.910	− 1.43	0.451	−0.56	0.867	1.97	0.542
year 4	5.28	0.095	7.41	0.035	−0.64	0.936	−31.4	0.233	−1.97	0.703	−0.04	0.994	^a	^a
year 5	1.83	0.564	4.41	0.212	6.59	0.263	1.57	0.934	1.71	0.650	0.87	0.887	−0.31	0.967
year 6	3.88	0.198	6.68	0.045	5.71	0.187	−4.74	0.738	0.65	0.824	−5.76	0.242	−10.5	0.121
Age (yr)	0.24	0.010	0.19	0.035	0.04	0.667	−0.31	0.894	0.24	< 0.001	− 0.14	0.248	0.04	0.759
Gender (F)	−6.54	0.024	−0.80	0.768	5.62	0.051	20.61	0.001	7.74	< 0.001	−14.26	< 0.001	−14.0	< 0.001
Smoking (yes)	−1.05	0.712	1.49	0.580	1.60	0.575	−0.84	0.894	−0.77	0.607	−7.31	0.044	−7.41	0.064
Pleurodesis
Unilateral	−4.02	0.165	−5.32	0.059	−0.59	0.859	5.82	0.422	3.24	0.068	0.32	0.938	4.27	0.354
Bilateral	−12.96	< 0.001	−14.72	< 0.001	−4.68	0.249	15.82	0.068	7.98	< 0.001	0.96	0.834	6.29	0.263

FEV₁ forced expiratory volume in one second, FVC forced vital capacity, TLC total lung capacity, RV residual volume, DLco carbon monoxide transfer factor, DLco/V_A carbon monoxide transfer coefficient, yr year, F female, %pred percentage of predicted value, β partial regression coefficient. Linear mixed model. ^aomitted due to missing data

ISSN: 1750-1172