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Table 4 Multivariable linear mixed model of the associations between clinical characteristics and lung function during follow-up

From: Lung function in Birt-Hogg-Dubé syndrome: a retrospective analysis of 96 patients

VariableFEV1
(%pred)
FVC
(%pred)
TLC
(%pred)
RV
(%pred)
RV/TLC
(%)
DLco
(%pred)
DLco/VA
(%pred)
βpβpβpβpβpβpβp
Time
year 12.230.1223.220.0451.450.511−5.800.402−1.590.2651.310.629−2.040.421
year 2−1.150.4760.140.937−0.470.862−12.950.111−3.180.055−0.970.745−4.150.127
year 30.920.5982.370.2345.970.043−10.70.910− 1.430.451−0.560.8671.970.542
year 45.280.0957.410.035−0.640.936−31.40.233−1.970.703−0.040.994aa
year 51.830.5644.410.2126.590.2631.570.9341.710.6500.870.887−0.310.967
year 63.880.1986.680.0455.710.187−4.740.7380.650.824−5.760.242−10.50.121
Age (yr)0.240.0100.190.0350.040.667−0.310.8940.24< 0.001− 0.140.2480.040.759
Gender (F)−6.540.024−0.800.7685.620.05120.610.0017.74< 0.001−14.26< 0.001−14.0< 0.001
Smoking (yes)−1.050.7121.490.5801.600.575−0.840.894−0.770.607−7.310.044−7.410.064
Pleurodesis
Unilateral−4.020.165−5.320.059−0.590.8595.820.4223.240.0680.320.9384.270.354
Bilateral−12.96< 0.001−14.72< 0.001−4.680.24915.820.0687.98< 0.0010.960.8346.290.263
  1. FEV1 forced expiratory volume in one second, FVC forced vital capacity, TLC total lung capacity, RV residual volume, DLco carbon monoxide transfer factor, DLco/VA carbon monoxide transfer coefficient, yr year, F female, %pred percentage of predicted value, β partial regression coefficient. Linear mixed model. aomitted due to missing data