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Table 1 Comparison of clinical findings between different PIG/PGAP genes (PIGA, PIGL, PIGV, PIGM, PIGN, PIGO, PIGG, PIGT, PGAP1, PGAP2, PGAP3)

From: The Glycosylphosphatidylinositol biosynthesis pathway in human diseases

Genes Steps Related diseases Total number of patients Median age at seizure onset Median age at death Number of deaths
PIGA 1 MCAHS2 31 6 m 2.78 m 12
PIGL 2 HPMRS5 17 5 m 1y 1
PIGM 6 GPIBD1 7 3.75y 5.5y 2
PIGV 7 HPMRS1 23 7 m 10y 1
PIGN 8 MCAHS1 30 3 m 19d 18
PIGO 10 HPMRS2 18 1.83y 1.75y 8
PIGG 11 MRT53 7 4 m 0
PIGT 12 MCAHS3 13 5 m 7y8m 5
PGAP2 Remolding HPMRS3 15 7y 0
PGAP3 Remolding HPMRS4 33 4y 0
PGAP1 Remolding GPIBD9 10 3 ma 0
  1. aOnly one patient’s onset age is available