Table 1 Comparison of clinical findings between different PIG/PGAP genes (PIGA, PIGL, PIGV, PIGM, PIGN, PIGO, PIGG, PIGT, PGAP1, PGAP2, PGAP3)
From: The Glycosylphosphatidylinositol biosynthesis pathway in human diseases
Genes | Steps | Related diseases | Total number of patients | Median age at seizure onset | Median age at death | Number of deaths |
|---|---|---|---|---|---|---|
PIGA | 1 | MCAHS2 | 31 | 6 m | 2.78 m | 12 |
PIGL | 2 | HPMRS5 | 17 | 5 m | 1y | 1 |
PIGM | 6 | GPIBD1 | 7 | 3.75y | 5.5y | 2 |
PIGV | 7 | HPMRS1 | 23 | 7 m | 10y | 1 |
PIGN | 8 | MCAHS1 | 30 | 3 m | 19d | 18 |
PIGO | 10 | HPMRS2 | 18 | 1.83y | 1.75y | 8 |
PIGG | 11 | MRT53 | 7 | 4 m | – | 0 |
PIGT | 12 | MCAHS3 | 13 | 5 m | 7y8m | 5 |
PGAP2 | Remolding | HPMRS3 | 15 | 7y | – | 0 |
PGAP3 | Remolding | HPMRS4 | 33 | 4y | – | 0 |
PGAP1 | Remolding | GPIBD9 | 10 | 3 ma | – | 0 |