Table 3 Change in mNIS+7 by components and subgroups at 24 months of patisiran treatment
Change from baseline to Month 24 | |||
|---|---|---|---|
n | Mean (SEM) | Median (range) | |
mNIS+7 component | |||
Total | 26 | −6.95 (2.03) | −7.00 (−34.63 to 15.38) |
NIS-Weakness | 26 | 1.23 (1.43) | 0.00 (−13.50 to 24.38) |
NIS-Reflexes | 26 | −0.48 (0.53) | 0.00 (−6.00 to 7.00) |
QST | 26 | −7.4 (2.04) | −6.0 (−40.0 to 16.0) |
NCS ∑5 | 26 | −0.19 (0.18) | −0.25 (−2.00 to 2.50) |
Postural BP | 26 | −0.10 (0.06) | 0.00 (−1.00 to 0.50) |
mNIS+7 by TTR tetramer stabilizer use | |||
Patisiran alone | 7 | −6.75 (5.24) | −8.50 (−28.50 to 15.38) |
Patisiran + TTR tetramer stabilizer | 19 | −7.03 (2.11) | −6.63 (−34.63 to 3.88) |