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Table 2 Differential diagnosis of diarrhea caused by Satoyoshi syndrome

From: Gastrointestinal manifestations in Satoyoshi syndrome: a systematic review

 Similarities with Satoyoshi syndromeDifferences with Satoyoshi syndrome
Celiac sprueMost frequent in women in the first decades of life.
Diarrhea with nutrient malabsorption
Immune basis
Iron deficiency anemia
Weight loss
Associated with other conditions such as autoimmune thyroid disease or myasthenia gravis. It can associate with rare manifestations such as infertility, arthralgia, arthropathy or alopecia.
Intestinal biopsies with inflammatory infiltrate
Improvement with gluten free diet. Muscle spasm or cramps not present
Drug induced DiarrheaDiarrhea Duodenitis with inflammatory infiltrate in biopsiesImprovement after drug withdrawal Muscle spasm and alopecia are not present
Inflammatory bowel diseaseDiarrhea and weight loss It can be present in young patientsInflammatory diarrhea, proctitis, bloody diarrhea, tenesmus, perianal fistulas, stenotic or fibrotic alterations osteoarticular involvement in form of migratory and asymmetric polyarthritis. In SS, bone deformities and alterations in the metaphysis are more frequent.
Irritable bowel syndromeIncreased frequency of bowel movementsNo signs of malabsorption or malnutrition. Associated with fibromyalgia, chronic fatigue syndrome, chronic back pain, chronic pelvic pain, chronic headache, and temporomandibular joint dysfunction, depression, anxiety
Autoimmune enteropathyImmune-mediated intestinal mucosal atrophy can be cause of watery diarrheaAlopecia, muscle spasms and skeletal alterations are nor present in autoimmune enteropathy