Table 2 Clinical characteristics of patients with and without neurological manifestations when treatment was initiated
|  | Symptomatic n = 24 | Asymptomatic n = 24 | p | ||
|---|---|---|---|---|---|
Male gender (%) | 11 (45.8) | 13 (54.2) | 0.564 | ||
Japanese ethnicity (%) | 8 (33.3) | 4 (16.7) | 0.182 | ||
Natural history | |||||
 Age at first manifestations, y | 35 (26–49) | 36.5 (20–43) | 0.443 | ||
 Age at first neurological manifestations, y | 51 (48.5–55) | – | – | ||
Treatment and clinical outcomes | |||||
 Age at start of treatment, y | 55 (50.5–59) | 39.5 (35–49) | 0.001 | ||
 Duration of treatment, m | 14 (5.5–48) | 72 (24–120) | 0.001 | ||
 Age at end of follow-up, y | 58 (54–63) | 53 (47–61) | 0.08 | ||
 Age at first neurological manifestations, y | – | 50 (45–55) | n = 9 | – | |
 Age at death, y | 60 (56–65.5) | n = 8 | 67 | n = 1 | – |