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Table 3 Model parameters

From: Natural history of lung function in spinal muscular atrophy

  Fixed EffectsRandom effects
 nIntercept (SE)95% CI InterceptSlope95% CI
Slope
Std. dev. InterceptStd. dev. Slope
FEV1
 SMA type 1c642.13 (4.58)33.89; 50.59−0.40−1.42; 0.60 (n.s.)6.111.12
 SMA type 2a4661.71 (4.51)52.44; 70.60−1.29− 1.78; − 0.8124.351.21
 SMA type 2b3481.37 (6.15)68.36; 93.53−1.37−2.04; − 0.7325.061.18
 SMA type 3a4197.61 (6.30)84.80; 110.02−0.73−1.11; − 0.3523.200.64
 SMA type 3b32100.35 (9.17)81.91; 118.90−0.11*− 0.55; 0.32 *(n.s.)16.62n/a*
FVC
 SMA type 1c549.71 (7.34)34.65; 68.07−1.15−3.29; 0.70 (n.s.)12.601.70
 SMA type 2a4764.20 (5.29)53.65; 74.64−1.32−1.90; −0.7628.461.39
 SMA type 2b3484.53 (6.07)71.85; 96.50−1.40−2.10; −0.7123.681.28
 SMA type 3a4396.65 (6.17)84.08; 108.73−0.67−1.06; − 0.3123.140.63
 SMA type 3b34109.00 (7.42)94.46; 123.50−0.23*−0.58; 0.11* (n.s.)15.35n/a*
VC
 SMA type 1c644.09 (7.06)28.41; 60.01−0.78−2.35; 0.63 (n.s.)12.841.21
 SMA type 2a3261.01 (4.62)51.78; 70.16−1.57−2.23; −0.9423.171.40
 SMA type 2b2285.54 (6.98)69.33; 98.18−1.65−2.59; −0.6025.041.46
 SMA type 3a1696.34 (9.05)78.17; 114.60−1.06−1.71; −0.4530.070.98
 SMA type 3b480.99 (19.67)35.90; 124.820.21−0.77; 1.23 (n.s.)35.120.75
  1. Legend: Model parameter estimates, standard errors, and confidence intervals for the linear mixed-effects models are shown. n: number of patients in each group
  2. SE standard error, CI confidence interval, Std. dev standard deviation, n.s. slope parameter is not significant; n/a not available
  3. * due to a too limited number of repeated-measurements ‘age at measurement’ was omitted as a random factor from the mixed-effects model. The slope parameter (i.e. the annual rate of decline in % of predicted) will therefore likely be an overestimation of the true value