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Table 3 Clinical and genetic characteristics of each individual patient with WRS

From: Diabetes management in Wolcott-Rallison syndrome: analysis from the German/Austrian DPV database

 Data at diabetes onsetData at patient’s last clinic visitComplicationsGenetic characteristics
SexAge (y)Ins (IU/kg/d)HbA1c (%)DKAAge (y)BMI-SDSIns (IU/kg/d)HbA1c (%)SHDKAMutation in EIF2AK3Migrational backgroundCSG
P 1f0n.a.n.a.n.a.410.58n.a.n.a.n.a.n.a.n.a.
P 2f0.10.57yesdied (0.6)n.a.0.571nonen.a.parents: Turkey; patient: born in GERn.a.
P 3f0.10.7n.a.yes1.80.750.59.5nonenonecompound heterozygous c.1474 C > T, p.Arg492*; c.2081 C > G, p.Ser694*parents: Syria; patient: born in GERyes
P 4f0.3n.a.n.a.yesdied (9)−1.751.5911homozygous c.1A > G, p.Met?parents: Afghanistan; patient: born in Iranunclear
P 5f0.20.79yesdied (5)−1.250.987nonehomozygous c.568_575dupGATGATGT, p.Val193Metfs10*parents: Russia; patient: born in GERno
P 6m0.21.16yes21.250.77nonenonehomozygous c.997C > T, p.Gln333*parents: Iraq; patient: born in GERyes
P 7m0.20.55.6no15.5n.a.0.78.6nonenonehomozygous c.2707C > T, p.Arg903*parents: Kosovo; patient: born in Austriano
P 8f0.30.7912.7yes1−0.750.78nonenonehomozygous p.Arg903*parents: Albania; patient: born in GERno
P 9m0.3n.a.n.a.yes12−11.19nonenonehomozygous c.2707C > T, p.Arg902*parents: Kosovo; patient: born in GERno
P 10*f0.1n.a.n.a.no20.25184nonehomozygous c.2707C > T, p.Arg903*parents: Kosovo; patient: born in GERno
P 11*f1.3n.a.n.a.no5−0.250.97nonenonehomozygous c.2707C > T, p.Arg903*parents: Kosovo; patient: born in Kosovono
  1. CSG: consanguinity, DKA: diabetic ketoacidosis, GER: Germany, Ins: insulin dose, n.a.: data not available, SH: severe hypoglycaemia. *these patients are siblings. great-grandparents related, status in parents unclear