Fig. 1
Conceptual Modela. aThe black arrow indicates a direct relationship between concepts. Grey arrows indicate that emotional, social, and work concepts may also be indirect impacts. bConcepts are in order by frequency of report and concepts reported by ≥ 50% of the sample are bolded. The conceptual model is primarily based on patient interviews using caregiver input as confirmatory. cThe dotted box includes all the sub-domains of the functional limitations of late-onset GM2 gangliosidosis