From: Hereditary haemorrhagic telangiectasia and pregnancy: a review of the literature
Study (Author, type) | Women (n) / Pregnancies (n) | Live births (n) | Results | Death n (% of pregnancies) | Known diagnosis (%) / rate of patients screened for PAVM / CAVM | Obstetrics events | Route of delivery V D (%) / C S (%) |
---|---|---|---|---|---|---|---|
Goodman et al. 1967 Retrospective | 40 / 97 +  80/213 controls | 78 | no statistically significant difference between the 2 groups (HHT and control) | NA | 100 / - / - | Miscarriage 14.4 vs 10% Abnormal outcome 50 vs 42% Prematurity 9.4 vs 10.3% Stillbirth 3.1 vs 2.6% | NA |
Shovlin et al. 1995 Retrospective | 47/161 | NA | 11 severe events (6.8% of pregnancies) PAVM shunt deterioration n = 6 Cerebro vascular accident n = 3 Fatal Pulmonary hemorrhage n = 2 10/11 events in the « PAVM + » group | 3 (1.9) | 100 / - / - | No Significant difference in the Miscarriage rate between the « PAVM + » and « PAVM – » group | NA |
Shovlin et al. 2008 Prospective+retrospective | 199/484 | NA | 13 severe events (2.7% of pregnancies) Myocardial infarction n = 1 (died) Cerebro vascular accident n = 6 (2 died / 2 ischaemic, 3 haemorrhagic, 1 NA) Pulmonary hemorrhage n = 6 (2 died) | 5 (1) | 26 / - / - |  | NA |
Wain et al. 2012 Retrospective | 226/560 | 457 | NA | NA | 100 / - / - | T1 Miscarriage 14.3% Preeclampsia 0.6% PPH 6.2% Prematurity 13.8% LBW 10.7% | 73.5 / 20.6 |
De Gussem et al. 2014 Retrospective | 87 / 244 | 185 | 15 severe events (6.1% of pregnancies) Heart failure n = 1 Hemothorax n = 4 (4 undiagnosed PAVMS) Hemoptysis n = 2 Transient Ischaemic attack n = 2 Post partum: Deep veinous thrombosis n = 1 Pulmonary embolism n = 1 Myocardial ischemia n = 2 Intracranial hemorrhage n = 1 Hemothorax n = 1 | NA | 100 / 13 / 17 | Miscarriage 20% Gestational hypertension 2.7% Preeclampsia 7% Eclampsia 0.5% Diabetes 3.2% PPH 2% Prematurity 12% | 70 / 30 |
Total | 599 / 1546 | 720 | Â | Â | Â | Â | Â |