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Table 2 Cognitive Functioning Results

From: Classical galactosemia: neuropsychological and psychosocial functioning beyond intellectual abilities

Domain

N

Results patients

P-valuea

N

FSIQ 50–69 (Group 1)

N

FSIQ 70–85

(Group 2)

N

FSIQ > 85

(Group 3)

P-valueb

Learning & Memory

 - AVLT Immediate Recall

 - AVLT Delayed Recall

 - AVLT Delayed / Immediate

 - Digit span

19

19

19

35

46.0 (9–61)

46.0 (15–65)

52.0 (38–65)

43.0 (20–63)

0.029

0.545

0.445

< 0.0005c

4

4

4

8

40.0 (9–46)

49.5 (15–58)

55.5 (43–62)

30.00 (20–57)

11

11

11

15

45.00 (35–61)

46.00 (34–65)

52.00 (38–65)

43.00 (27–60)

4

4

4

12

49.50 (47–51)

50.00 (43–55)

52.00 (39–62)

48.50 (33–63)

0.121

0.956

0.803

0.017

Visuospatial functioning

 GIT-2 spatial test

 Block design

19

42

36.0 (23–50)

38.5 (20–53)

< 0.0005c

< 0.0005c

4

9

26.5 (23–40)

30.0 (20–40)

11

17

35.0 (28–40)

37.0 (27–50)

4

16

41.5 (40–50)

37.0 (33–53)

0.019

< 0.0005c

Executive functioning

Inhibition

 - Stroop III (Inhibition)

 - Stroop III/II (Interference)

25

25

45.0 (20–56)

49.0 (30–66)

0.003c

0.537

6

6

27.0 (20–49)

43.0 (30–60)

13

13

48.00 (22–56)

50.00 (31–66)

6

6

46.0 (35–53)

47.5 (40–63)

0.078

0.642

Cognitive flexibility

 - WCST Total number of errors

 - WCST Perseverative responses

 - WCST Percent Cconceptual level responses

24

24

24

50.5 (27–67)

51.0 (30–81)

49.5 (27–64)

0.988

0.626

0.951

6

6

6

46.0 (27–50)

46.0 (33–52)

48.0 (27–51)

12

12

12

51.50 (37–67)

53.00 (30–81)

52.00 (39–64)

6

6

6

52.0 (39–64)

52.0 (35–73)

51.0 (37–62)

0.134

0.278

0.270

Responses

 - TMT B/A

 - Letter fluency

25

19

44.0 (27–57)

37.0 (27–67)

0.002c

0.001c

6

4

45.0 (27–50)

31.0 (28–38)

13

11

43.00 (27–57)

39.00 (31–67)

6

4

48.5 (40–57)

34.0 (27–56)

0.510

0.143

Mental Speed

- Stroop I (Color naming)

- Stroop II (Word reading)

- TMT A (Digit sequencing)

- TMT B (Digit-Letter-Switching)

- Symbol search

- Substitution

25

25

25

25

41

42

40.0 (25–61)

37.0 (20–56)

52.0 (20–67)

45.0 (20–58)

43.0 (20–67)

40.0 (23–57)

0.001c

< 0.0005c

0.352

0.003c

< 0.0005c

< 0.0005c

6

6

6

6

9

9

35.0 (25–43)

30.0 (20–40)

50.5 (20–59)

33.5 (20–47)

23.0 (20–50)

30.0 (23–47)

13

13

13

13

17

17

43.00 (35–61)

43.00 (20–56)

56.00 (43–67)

46.00 (20–58)

40.00 (27–67)

40.00 (30–57)

6

6

6

6

15

16

46.5 (33–55)

39.0 (33–56)

47.5 (33–67)

45.0 (33–56)

47.0 (40–60)

43.0 (33–53)

0.077

0.063

0.173

0.111

0.001c

0.006

  1. Data reported in T-scores, median (ranges). a Patient data vs. normative data (T-score 50), b Comparison between FSIQ groups, c Significant after Bonferroni-Holm correction. FSIQ full scale IQ, AVLT auditory verbal learning test, GIT-II groninger intelligentie test 2, Stroop stroop color word test, WCST wisconsin card sorting test, TMT trail making test