Fig. 2

a Patient 1 presented with a cauliflower-like tumor at the right lower leg. The tumor did not regress after 4 cycles of cetuximab. b MRI and ¹⁸F-FGD-PET/CT at baseline showed hypermetabolic enlarged node metastases (white and black arrows, respectively) in the left axilla and pelvis (upper panel). Five months after cetuximab initiation a decrease of the axillary lymph node metastasis in size and metabolism was observed, while only a faint residuum was noticeable in the pelvic region (lower panel). Also note the increased bone marrow activity due to concomitant inflammatory reactions associated with the chronic wounds in EB. c IHC of the primary tumor of patient 1 revealed positive EGFR staining (red)