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Fig. 4 | Orphanet Journal of Rare Diseases

Fig. 4

From: Developmental hypomyelination in Wolfram syndrome: new insights from neuroimaging and gene expression analyses

Fig. 4

Temporal expression of WFS1 and cell type-specific expression of WFS1-related genes. a) Left: Mean WFS1 spatiotemporal expression (RPKM, or reads per kilobase per million) in 16 brain regions and 5 developmental time periods from the BrainSpan database (8–26 post-conception weeks (pcw), 4 months-4 years, 8 years–15 years, 18 years–23 years, and 30 years–40 years). Right: Mean WFS1 spatiotemporal expression normalized to each brain region’s expression across time. b) Cell-type specific expression in the human brain of WFS1-related genes. Gene list derived from BrainSpan database brains 8pcw-40 yrs. c) Cell-type specific expression in the human brain of WFS1-related genes, derived from the BrainCloud database (prefrontal cortex). d) Cell-type specific expression in the human brain of WFS1-related genes. Gene list derived from BrainSpan database, ages 4 months-4 years. e) Key to CSEA map. Hexagon size is scaled to gene list length, and each concentric ring corresponds with specificity index threshold (pSI) which decreases as the number of relatively enriched transcripts decreases and the remaining subset is relatively more specific. Map key reprinted with permission from [68]

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