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Fig. 3 | Orphanet Journal of Rare Diseases

Fig. 3

From: Cardiovascular progenitor cells and tissue plasticity are reduced in a myocardium affected by Becker muscular dystrophy

Fig. 3

Results on the cardiac tissue analysis. a FACS analysis of c-kit+/CD45 cells from dystrophin-deficient regions in different areas of the organ. b Comparison of c-kit+/CD45 cells percentage fractions among negative controls (HD, left atrium) and the dystrophin-deficient heart (indicated parts), * = p < 0.05. c Maximum distance reached by fibroblasts at the end of the migration assay, statistical difference was assessed using Mann-Whitney test. (*** = p < 0.001, d Tissue sample images on an optical microscope: top row, bright field images show migrating fibroblasts from healthy samples, while few cells migrated from dystrophin-deficient samples; bottom row shows phase-contrast close-ups of the explants. HD fibroblast layers are covered by phase-bright cells (left, dashed area + red arrows), while dystrophin-deficient layers show only sparse migration of these cells (right, red arrows show examples)

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