Fig. 6

A 57-year-old patient with macrocytosis and liver steatosis. a, b The CT pattern was considered indeterminate for UIP, not suggestive of a specific diagnosis. Genetic analysis revealed a heterozygous TERC mutation (r.235C > G) classified as pathogenic, and genetic counseling was proposed for the relatives. Lung transplantation was proposed and performed in August 2018. c Histology of the lung transplant tissue was considered indeterminate for UIP: patchy fibrosis with both subpleural and centrilobular fibrosis (*) with dense inflammatory infiltrates and fibroblastic foci (>). (*), b: bronchiole. Hematoxylin Eosin Saffron stain, bar = 3000 μm