Table 3 Genetics and cardiac manifestations of LMNA mutated patients without neurological onset (N = 26)

M; 53 yo

LMNA

Exon 6

c.1004G > A

p.Arg335Gln

Missense

M; 26 yo

LMNA

Exon 6

c.1004G > A

p.Arg335Gln

Missense

F; 47 yo

LMNA

Exon 7

1370delA

p.Lys457SerfsX2

Deletion

M; 19 yo

LMNA

Exon 6

c.1003G > A

p.Arg335Glu

Missense

F; 55 yo

LMNA

Exon 11

c.1912G > A

p.Gly638Arg

Missense

M; 54 yo

LMNA

Exon 7

c.1202G > A

p.Arg401His

Missense

M; 42 yo

LMNA

Exon 1

n/a

p.Arg72Alafs*24

Frame shift

F; 51 yo

LMNA

Exon 4

c.752A > C

p.Gln251Pro

Missense

M; 46 yo

LMNA

Exon 9

c.1517 A > C

p.His506Pro

Missense

F; 38 yo

LMNA

Intron 9

c1608 + 1G > T

–

Splice site

M; 35 yo

LMNA

Intron 9

c1608 + 1G > T

–

Splice site

F; 29 yo

LMNA

Exon 3

c.548 T > C

p.Leu183Pro

Missense

F; 41 yo

LMNA

Exon 6

c.1007G > A

p.Arg336Gln

Missense

M; 60 yo

LMNA

Intron 1

c.357-1G > A

IVS1-1G > A

–

Splice site

F; 46 yo

LMNA

Intron 1

c.357-1G > A

IVS1-1G > A

–

Splice site

F; 49 yo

LMNA

Intron 1

c.357-1G > A

IVS1-1G > A

–

Splice site

F; 49 yo

LMNA

Intron 1

c.357-1G > A

IVS1-1G > A

–

Splice site

M; 21 yo

LMNA

Intron 1

c.357-1G > A

IVS1-1G > A

–

Splice site

M; 38 yo

LMNA

Exon 6

c.1129C > T

p.Arg377Cys

Missense

M; 50 yo

LMNA

Exon 2

c.481G > A

p.Glu161Lys

Missense

M; 46 yo

LMNA

Exon 2

c.466C > A

p.Arg156Ser

Missense

M; 34 yo

LMNA

Exon 2

c.466C > A

p.Arg156Ser

Missense

M; 44 yo

LMNA

Exon 4

c.671 C > T

p.Thr224Ile

Missense

F; 39 yo

LMNA

Exon 2

c.481G > A

p.Glu161Lys

Missense

F; 37 yo

LMNA

Exon 2

c.513G > A

pLys171Asn

Missense

F; 36 yo

LMNA

Exon 5

c.855delG

p.Ala287LeufsX191

Deletion