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Table 4 Projected annual national incidence estimates for aTTP expressed as cases per million inhabitants in the overall population (total) and in adult patients (18+) related to the years 2014 to 2016

From: Incidence of acquired thrombotic thrombocytopenic purpura in Germany: a hospital level study

Projected national aTTP episodes (per million)Year 2016Year 2015Year 2014
MVLL 95%CIUL 95CIMVLL 95%CIUL 95%CIMVLL 95%CIUL 95%CI
aTTP cases per million in M31.1 PD (total)1.88*1.552.211.791.472.091.871.542.19
aTTP cases per million in M31.1 SD (total)0.240.080.410.290.100.480.220.070.37
Overall aTTP cases per million (total)2.121.632.622.081.572.572.091.612.56
 aTTP cases per million (initial) (total)1.491.311.591.461.261.561.471.281.55
 aTTP cases per million (recurrence) (total)0.630.321.030.620.311.010.620.331.01
 aTTP cases per million in M31.1 PD (18+)2.171.802.552.061.702.432.161.782.53
 aTTP cases per million cases in M31.1 SD (18+)0.290.090.480.330.120.570.250.090.43
Overall aTTP cases per million (18+)2.461.893.032.391.823.002.411.872.96
 aTTP cases per million (initial) (18+)1.721.511.821.691.451.821.691.491.80
 aTTP cases per million (recurrence) (18+)0.740.381.210.700.371.180.720.381.16
  1. * example calculation: 155 cases (Table 3 aTTP cases in M31.1 in 2016) per 82.5 million inhabitants in 2016 = 1.88 acute aTTP cases per million, ICD-10 M31.1 “Thrombotic Microangiopathy”, PD = Primary Diagnosis, SD = Secondary Diagnosis (SD); total = children, adolescents and adults; 18+ = adults; MV = mean value, LL 95%CI = lower limit 95% confidence interval; UL 95%CI = upper limit 95% confidence interval