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Table 3 Projected annual national acute aTTP cases in the overall population (total) and in adult patients (18+) related to the years 2014 to 2016

From: Incidence of acquired thrombotic thrombocytopenic purpura in Germany: a hospital level study

Projected national aTTP episodes

Year 2016

Year 2015

Year 2014

MV

LL 95%CI

UL 95CI

MV

LL 95%CI

UL 95%CI

MV

LL 95%CI

UL 95%CI

aTTP cases in M31.1 PD (total)

155*

128

182

148

122

173

152

125

178

aTTP cases in M31.1 SD (total)

20

7

34

24

8

40

18

6

30

Overall aTTP cases (total)

175

135

216

172

130

213

170

131

208

 aTTP cases (initial manifestation) (total)

123

108

131

121

104

129

119

104

126

 aTTP cases (recurrence) (total)

52

27

85

51

26

84

51

27

82

 aTTP cases in M31.1 PD (18+)

150

124

176

142

117

167

147

121

172

 aTTP cases in M31.1 SD (18+)

20

6

33

23

8

39

17

6

29

Overall aTTP cases (18+)

170

130

209

165

125

206

164

127

201

 aTTP cases (initial manifestation) (18+)

119

104

126

116

100

125

115

101

122

 aTTP cases (recurrence) (18+)

51

26

83

49

25

81

49

26

79

  1. *example calculation: 37.3% (Fig. 3 M31.1 primary diagnosis (%)) × 416 cases (Table 1 M31.1 PD (total)) = 155.2 cases (rounded = 155 cases), ICD-10 M31.1 “Thrombotic Microangiopathy”, PD = Primary Diagnosis, SD = Secondary Diagnosis (SD); total = children, adolescents and adults; 18+ = adults; MV = mean value, LL 95%CI = lower limit 95% confidence interval; UL 95%CI = upper limit 95% confidence interval