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Table 3 Projected annual national acute aTTP cases in the overall population (total) and in adult patients (18+) related to the years 2014 to 2016

From: Incidence of acquired thrombotic thrombocytopenic purpura in Germany: a hospital level study

Projected national aTTP episodesYear 2016Year 2015Year 2014
MVLL 95%CIUL 95CIMVLL 95%CIUL 95%CIMVLL 95%CIUL 95%CI
aTTP cases in M31.1 PD (total)155*128182148122173152125178
aTTP cases in M31.1 SD (total)207342484018630
Overall aTTP cases (total)175135216172130213170131208
 aTTP cases (initial manifestation) (total)123108131121104129119104126
 aTTP cases (recurrence) (total)522785512684512782
 aTTP cases in M31.1 PD (18+)150124176142117167147121172
 aTTP cases in M31.1 SD (18+)206332383917629
Overall aTTP cases (18+)170130209165125206164127201
 aTTP cases (initial manifestation) (18+)119104126116100125115101122
 aTTP cases (recurrence) (18+)512683492581492679
  1. *example calculation: 37.3% (Fig. 3 M31.1 primary diagnosis (%)) × 416 cases (Table 1 M31.1 PD (total)) = 155.2 cases (rounded = 155 cases), ICD-10 M31.1 “Thrombotic Microangiopathy”, PD = Primary Diagnosis, SD = Secondary Diagnosis (SD); total = children, adolescents and adults; 18+ = adults; MV = mean value, LL 95%CI = lower limit 95% confidence interval; UL 95%CI = upper limit 95% confidence interval