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Table 4 Complement autoantibody patterns in clusters of 106 IC-MPGN/C3G patients who have full data-set for all of the autoantibodies

From: C4 nephritic factor in patients with immune-complex-mediated membranoproliferative glomerulonephritis and C3-glomerulopathy

Autoantibody, positivity/ patientPattern of autoantibody positivity (number of patients affected)cluster 1 (n = 46)cluster 2 (n = 4)cluster 3 (n = 20)cluster 4 (n = 36)Row total
0None17 (28%)3 (5%)13 (21%)28 (46%)61 (100%)
1C3NeF (14)18 (56%)0 (0%)6 (19%)8 (25%)32 (100%)
C4NeF (8)
anti-FH (3)
anti-C1q (4)
anti-FB (3)
2anti-C1q + anti-FH (1)6 (100%)0 (0%)0 (0%)0 (0%)6 (100%)
anti-C1q + anti-C3 (1)
anti-C1q + C4NeF (1)
C3NeF + C4NeF (3)
> 2anti-C1q + anti-FH + anti-FB (1)5 (72%)1 (14%)1 (14%)0 (0%)7 (100%)
anti-C1q + anti-FH+ anti-C3 (1)
C3NeF + anti-FB + anti- C1q (1)
C3NeF + C4NEF + anti-Cq (2)
C3NeF + C4NeF + anti-C3 + anti-C1q (1)
C3NeF + C4NeF + anti-C3-anti-FB (1)
  1. P = 0.003, chi-square test
  2. Significance level was determined at a value of p < 0.05