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Table 2 Complement parameters of IC-MPGN/C3G patients with and without C4NeF

From: C4 nephritic factor in patients with immune-complex-mediated membranoproliferative glomerulonephritis and C3-glomerulopathy

 C4NeF positive patients
n = 17
C4NeF negative patients
n = 102
p
serum C4 (0.15–0.55 g/L)0.2 (0.12–0.26)0.23 (0.17–0.32)0.232
serum C3 (0.9–1.8 g/L)0.33 (0.19–0.98)0.73 (0.39–01)0.115
Classical pathway activity (48–103 CH50/mL)30 (11–54)46 (28–61)0.065
Alternative pathway activity (70–125%)40 (0–67)63 (3–87)0.055
C3NeF positivity (< 10%)7(41)20 (19.6)0.063
C1q (60–180 mg/L)108 (83–138)102 (83–123)0.528
anti-C1q (< 52 U/mL)4 (23.5)10 (9.8)0.117
C4d (0.7–6.3 ng/mL)3.23 (2.6–5.3)5.46 (3.15–9.27)0.038
  1. Reference ranges are shown in the first coloumn in parentheses. The data are given as median and interquartile range or number and percentages. P-values are given as the results of χ2 or Mann-Whitney tests
  2. There are some missing values in the following data: C1q (n = 13), C4d (n = 23), anti-C1q (n = 8)
  3. Significance level was determined at a value of p < 0.05