From: Biliary tract large cell neuroendocrine carcinoma: current evidence
Case | Ref. | Age (yr) | Sex | Site | Presentation | Metastasis | Chemo | Surgery | Outcomea |
---|---|---|---|---|---|---|---|---|---|
1 | [6] | 65 | M | GB | Symptomatic Cholelithiasis | Liver (4mn after CCY) | Chemo NS | CCY LR | Died 18 mo |
2 | [16] | 55 | M | GB | Abdominal Pain + Jaundice | Multiple LN | Chemo NS (1 cycle) | Celiac LN Bx; unresect | Died 1 mo |
3 | [16] | 67 | F | GB | Abdominal Pain | Liver | Chemo NS (3 cycles) | Liver/GB Bx, unresect | Died 10 mo |
4 | [15] | 58 | F | GB | 18mo hx Suggestive of Gallstone | Regional LN | Cis + ETP (5 cycles, adjuvant) | CCY → 2 mo later radical GB Bed Clearance, Partial LR, CBD excision, and LND up to coeliac nodes | Alive (16 mo post-CCY) |
5 | [17] | 64 | F | GB | Abdominal Pain | Liver / Brain | Hepatic Arterial Chemo Infusion: Cis/ETP + CAV + Pre-op 3D RT Post-op Chemo with Cis/ETP | RHep Triseg; Cerebell +γ-knife | Died 69mo after 1st diagnosis (3 yr without recurrence since the last γ-knife) |
6 | [10] | 67 | F | GB CBD | Abdominal Pain + Jaundice | Multiple LN; Liver; Lung; Vertebra, Peritoneum | Cis + ETP (1 cycle) | Unresect | Died < 1 mo |
7 | [9] | 56 | M | GB | Exophthalmos | Liver; Ileum; Kidneys; Adrenal Glands; Diaphragm; Epicardium; Left Orbit; Abdominal LN | Chemo-radiotherapy NS | Unresect | Died 36 mo |
8 | [18] | 64 | M | GB | Abdominal Fullness | Liver; Multiple LN; Bone | Cis + TXT→ CBDCA + TXT | Axillary LN + GB Bx Unresect | Died 22 mo |
9 | [8] | 76 | M | CBD | Jaundice | Multiple LN; GB | None | RHepLob; Bile Duct Resection, CCY | Died 21 days |
10 | [13] | 75 | F | CBD | Nausea Jaundice | LN; → recurrence at HJ site; Liver; Portocaval Area | 5-FU+ EPR + CIS (adjuvant) | CBD excision with LN dissection | Died 12 mo |
11 | [11] | 76 | F | GB | Abdominal Pain with Cholelithiasis | Regional LN; Liver | Cis + ETP → CBDCA + ETP; SST (no carcinoid sxs) | CCY | Died 5 mo |
12 | [19] | 72 | M | CBD | Jaundice | Liver | Cis + ETP | RHepLob+ extra-hepatic BD and PV resection after Percu/ Trans-hepatic PV Embo | Alive 7mo post-surgery |