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Table 6 Number and percentages of poor cognitive scores in individuals who have followed or not followed European guidelines (Phe average < 360 in childhood; < 600 after that); Poor cognitive scores = > 1 SD worse than the controls. Z-score = mean z score in our cognitive battery

From: Adult cognitive outcomes in phenylketonuria: explaining causes of variability beyond average Phe levels

 

Childhood 0–10

Adolescence/Adult 11+

Guidelines

Diff.

χ2

Guidelines

Diff.

χ2

✓

✓

Phe AVERAGE

Phe < 360

Phe > 360

 

p

Phe < 600

Phe > 600

 

p

IQ

N

10/22

16/28

  

4/15

23/41

  
 

%

45.5

57.1

11.7

.30

26.7

56.1

29.4

.05

z-score

N

3/22

9/28

  

0/15

12/41

  
 

%

13.6

26.5

12.8

.12

0

29.3

29.3

.01

Phe SD

 

Phe < 180

Phe > 180

  

Phe < 180

Phe > 180

  

IQ

N

5/14

21/34

  

15/38

11/18

  
 

%

35.7

61.8

26.1

.09

42.2

61.1

19.0

.11

z-score

N

0/14

12/34

  

5/38

-7/18

  
 

%

0

35.3

35.3

.008

13.6

38.9

25.7

.03