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Table 6 Number and percentages of poor cognitive scores in individuals who have followed or not followed European guidelines (Phe average < 360 in childhood; < 600 after that); Poor cognitive scores = > 1 SD worse than the controls. Z-score = mean z score in our cognitive battery

From: Adult cognitive outcomes in phenylketonuria: explaining causes of variability beyond average Phe levels

 Childhood 0–10Adolescence/Adult 11+
GuidelinesDiff.χ2GuidelinesDiff.χ2
Phe AVERAGEPhe < 360Phe > 360 pPhe < 600Phe > 600 p
IQN10/2216/28  4/1523/41  
 %45.557.111.7.3026.756.129.4.05
z-scoreN3/229/28  0/1512/41  
 %13.626.512.8.12029.329.3.01
Phe SD Phe < 180Phe > 180  Phe < 180Phe > 180  
IQN5/1421/34  15/3811/18  
 %35.761.826.1.0942.261.119.0.11
z-scoreN0/1412/34  5/38-7/18  
 %035.335.3.00813.638.925.7.03