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Table 3 Pearson r correlations between Phe measures taken at different points in time and adult cognitive performance (N participants = 51–56; N tasks = 16). Significant correlations are in bold. a = significant <.05; b significant <.01. To facilitate interpretation, positive correlations always indicate that high Phe was associated with worse performance. Thus, for IQ, digit span, Corsi span, and semantic fluency correlations were reversed

From: Adult cognitive outcomes in phenylketonuria: explaining causes of variability beyond average Phe levels

PHE

 

Visual attention speed

Visuo Motor coordination

EF /Monitoring

Sustained

Learning and memory

FSIQ

Simple

Detection

Feature

Conjunction

Peg-

Digit

WCST

TMT

Digit

Corsi

Semantic

Attention

Rey

Rey

Paired Associate

 

RT

with distractors RT

Search RT

Search RT

board

Symbol

Total errors

B-A

span

Span

Fluency

RVP %

a1-a5

delayed

Visual learning

0–10 yrs

 Average

.20

.22

.30a

.33a

.34a

.18

.18

.09

.28a

.12

−.02

.28

.12

.06

.07

.34a

 SD

.43b

.43b

.56b

.41b

.44b

.40b

.15

.19

.47b

.37a

.06

.25

.31a

.35a

.36a

.53b

11–16 yrs

 Average

.32a

.14

.18

.33a

.27

.28a

.27

.32a

.22

.11

.09

.34a

.32a

.17

.14

.60b

SD

.40b

.16

.25

.25

.20

.40b

−.03

.21

.27

.30a

−.06

.42b

.32a

.07

.11

.42b

17 yr to now

 Average

.42b

.05

.29a

.35a

.32a

.24

.35a

.31a

.43b

.10

.05

.21

.38b

.28

.29a

.44b

 SD

.47b

.06

.26

.23

.15

.33a

.00

.26

.54b

.12

−0.1

.27a

.37b

−.03

.06

.23

Lifetime

 Average

.23

.13

.27

.40b

.40b

.18

0.28

.29a

.28a

.01

.04

.16

.19

.12

.12

.40b

 SD

.56b

.23

.43b

.29a

.24

.39b

0.07

.28a

.47b

.26

−0.04

.29a

.40b

.21

.29a

.48b

Current

.43b

.00

0.16

.09

.09

.26

.34a

.22

.55b

.05

−0.11

.17

.42b

.34a

.39b

.33a

  1. Note. Correlations have been carried out using z scores. For the English PKU sample the number of participants and available Phe measures is slightly different across tests (range 31–37 participants), this means that the same value of r may have different probabilities