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Table 2 Developmental Testing Scores at baseline, 6 months and at 12 months

From: A placebo-controlled trial of folic acid and betaine in identical twins with Angelman syndrome

Variables (Raw Scores) at 0, 6 and 12 months TWIN 0 6 12 cScore 6-0 cScore 12-6 c Total Score
Bayley Mental Aa 76 83 90 7 7 14
Bb 77 78 78 1 0 1
Ca 70 77 78 7 1 8
Db 73 73 76 0 3 3
Bayley Motor A 66 67 74 1 7 8
B 66 67 73 1 6 7
C 38 41 44 2 3 5
D 51 50 47 -1 −3 −4
Preschool Language Auditory Comprehension A 8 9 9 1 0 1
B 8 8 9 0 1 1
C 5 7 6 2 −1 1
D 5 5 7 0 2 2
Preschool Language Expressive Communication A 6 9 9 3 0 3
B 5 9 8 4 −1 3
C 6 6 6 0 0 0
D 4 3 3 −1 0 −1
Preschool Language Composite A 14 18 18 4 0 4
B 13 17 17 4 0 4
C 11 13 12 2 −1 1
D 9 8 10 −1 2 1
*Vineland Communication A 24 24 26 0 2 2
B 24 23 25 −1 2 1
C 12 14 16 2 2 4
D 14 15 14 1 −1 0
*Vineland Daily Living A 31 31 35 0 4 4
B 29 27 33 −2 6 4
C 7 6 6 −1 0 −1
D 8 9 8 1 − 1 0
*Vineland Socialization A 29 33 33 4 0 4
B 27 29 33 2 4 6
C 25 30 30 5 0 5
D 23 26 17 3 −9 −6
*Vineland Adaptive Behavior Composite A 164 117 131 −47 14 −33
B 80 105 127 25 22 47
C 139 131 106 −8 −25 −33
D 145 136 123 −9 −13 − 22
*Vineland Adaptive Behavior Composite (standard scores) A 29 28 27 −1 −1 −2
B 29 26 −3
C 32 30 32 −2 2 0
D 33 42 28 9 −14 −5
MacArthur Communicative Developmental Inventory Phrases understood A 25 25 16 0 −9 −9
B 19 22 15 3 −7 −4
C 2 0 0 −2 0 −2
D 0 0 2 0 2 2
MacArthur Communicative Developmental Inventory Vocabulary comprehension A 1 3 0 2 −3 −1
B 1 2 0 1 −2 −1
C 1 0 5 − 1 5 4
D 3 2 8 −1 6 5
MacArthur Communicative Developmental Inventory production A 0 0 1 0 1 1
B 0 2 0 2 −2 0
C 1 0 1 −1 1 0
D 0 0 0 0 0 0
  1. * Vineland did not include the motor skills portion because the twins were over age 6 years
  2. The labels a for placebo, and the label b for drug (betaine and folic acid) treatment applies to all the testing groups. c refers to differences in the scores between baseline, 6 months and 12 months
  3. P-values calculated through t-test were not statistically significant