Table 2 Developmental Testing Scores at baseline, 6 months and at 12 months
From: A placebo-controlled trial of folic acid and betaine in identical twins with Angelman syndrome
Variables (Raw Scores) at 0, 6 and 12 months | TWIN | 0 | 6 | 12 | cScore 6-0 | cScore 12-6 | c Total Score |
|---|---|---|---|---|---|---|---|
Bayley Mental | Aa | 76 | 83 | 90 | 7 | 7 | 14 |
Bb | 77 | 78 | 78 | 1 | 0 | 1 | |
Ca | 70 | 77 | 78 | 7 | 1 | 8 | |
Db | 73 | 73 | 76 | 0 | 3 | 3 | |
Bayley Motor | A | 66 | 67 | 74 | 1 | 7 | 8 |
B | 66 | 67 | 73 | 1 | 6 | 7 | |
C | 38 | 41 | 44 | 2 | 3 | 5 | |
D | 51 | 50 | 47 | -1 | −3 | −4 | |
Preschool Language Auditory Comprehension | A | 8 | 9 | 9 | 1 | 0 | 1 |
B | 8 | 8 | 9 | 0 | 1 | 1 | |
C | 5 | 7 | 6 | 2 | −1 | 1 | |
D | 5 | 5 | 7 | 0 | 2 | 2 | |
Preschool Language Expressive Communication | A | 6 | 9 | 9 | 3 | 0 | 3 |
B | 5 | 9 | 8 | 4 | −1 | 3 | |
C | 6 | 6 | 6 | 0 | 0 | 0 | |
D | 4 | 3 | 3 | −1 | 0 | −1 | |
Preschool Language Composite | A | 14 | 18 | 18 | 4 | 0 | 4 |
B | 13 | 17 | 17 | 4 | 0 | 4 | |
C | 11 | 13 | 12 | 2 | −1 | 1 | |
D | 9 | 8 | 10 | −1 | 2 | 1 | |
*Vineland Communication | A | 24 | 24 | 26 | 0 | 2 | 2 |
B | 24 | 23 | 25 | −1 | 2 | 1 | |
C | 12 | 14 | 16 | 2 | 2 | 4 | |
D | 14 | 15 | 14 | 1 | −1 | 0 | |
*Vineland Daily Living | A | 31 | 31 | 35 | 0 | 4 | 4 |
B | 29 | 27 | 33 | −2 | 6 | 4 | |
C | 7 | 6 | 6 | −1 | 0 | −1 | |
D | 8 | 9 | 8 | 1 | − 1 | 0 | |
*Vineland Socialization | A | 29 | 33 | 33 | 4 | 0 | 4 |
B | 27 | 29 | 33 | 2 | 4 | 6 | |
C | 25 | 30 | 30 | 5 | 0 | 5 | |
D | 23 | 26 | 17 | 3 | −9 | −6 | |
*Vineland Adaptive Behavior Composite | A | 164 | 117 | 131 | −47 | 14 | −33 |
B | 80 | 105 | 127 | 25 | 22 | 47 | |
C | 139 | 131 | 106 | −8 | −25 | −33 | |
D | 145 | 136 | 123 | −9 | −13 | − 22 | |
*Vineland Adaptive Behavior Composite (standard scores) | A | 29 | 28 | 27 | −1 | −1 | −2 |
B | 29 | – | 26 | – | – | −3 | |
C | 32 | 30 | 32 | −2 | 2 | 0 | |
D | 33 | 42 | 28 | 9 | −14 | −5 | |
MacArthur Communicative Developmental Inventory Phrases understood | A | 25 | 25 | 16 | 0 | −9 | −9 |
B | 19 | 22 | 15 | 3 | −7 | −4 | |
C | 2 | 0 | 0 | −2 | 0 | −2 | |
D | 0 | 0 | 2 | 0 | 2 | 2 | |
MacArthur Communicative Developmental Inventory Vocabulary comprehension | A | 1 | 3 | 0 | 2 | −3 | −1 |
B | 1 | 2 | 0 | 1 | −2 | −1 | |
C | 1 | 0 | 5 | − 1 | 5 | 4 | |
D | 3 | 2 | 8 | −1 | 6 | 5 | |
MacArthur Communicative Developmental Inventory production | A | 0 | 0 | 1 | 0 | 1 | 1 |
B | 0 | 2 | 0 | 2 | −2 | 0 | |
C | 1 | 0 | 1 | −1 | 1 | 0 | |
D | 0 | 0 | 0 | 0 | 0 | 0 |