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Table 6 Incidence of steroid-related complications by steroid treatment status

From: Real-world clinical course of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Japan

 

Patients with HAM/TSP without steroid therapy during the observation period (Untreated group, n = 185)

Patients with HAM/TSP with at least once steroid therapy during the observation period (Steroid group, n = 225)

Patients with HAM/TSP who had continued steroid therapy during the observation period (Continued steroid group, n = 181)

OMDS 1–4

46 (24.9%)

51 (22.7%)

39 (21.5%)

OMDS 5

54 (29.2%)

91 (40.4%)

71 (39.2%)

OMDS 6

34 (18.4%)

38 (16.9%)

34 (18.8%)

OMDS 7–13

51 (27.6%)

45 (20.0%)

37 (20.4%)

Steroid-related complications

Incidence

per 1000 person-yearsa

Incidence

per 1000 person-yearsa

Incidence

per 1000 person-yearsa

Bone fracture

48.3 (33.0–70.8)

61.0 (45.1–82.5)

65.6 (47.4–90.8)

 OMDS 1–4

42.9 (18.3–100.5)

33.4 (14.2–78.1)

35.0 (13.6–90.1)

 OMDS 5

26.2 (10.2–67.3)

76.5 (50.0–116.9)

83.4 (52.8–131.9)

 OMDS 6

72.4 (36.7–142.9)

60.3 (29.2–124.5)

48.4 (20.7–113.2)

 OMDS 7–13

56.8 (29.9–107.9)

60.9 (32.0–115.7)

77.9 (41.0–148.0)

 Lower limb fracture

21.8 (12.5–38.1)

24.2 (15.1–38.7)

26.7 (16.2–44.0)

 OMDS 1–4

0.0 (0.0–30.5)

6.6 (1.2–37.6)

8.7 (1.5–49.2)

 OMDS 5

25.8 (10.0–66.4)

25.1 (12.1–51.7)

c

 OMDS 6

35.6 (13.8–91.4)

8.4 (1.5–47.5)

0.0 (0.0–36.1)

 OMDS 7–13

25.4 (9.9–65.4)

51.8 (26.3–102.3)

65.6 (33.2–129.4)

 Compression fracture

16.1 (8.5–30.6)

25.4 (16.1–40.2)

28.1 (17.3–45.7)

 OMDS 1–4

8.4 (1.5–47.5)

13.1 (3.6–47.7)

17.1 (4.7–62.3)

 OMDS 5

0.0 (0.0–24.0)

28.3 (14.4–55.9)

26.8 (12.3–58.5)

 OMDS 6

35.5 (13.8–91.4)

42.4 (18.1–99.2)

47.5 (20.3–111.2)

 OMDS 7–13

23.8 (9.3–61.2)

19.4 (6.6–57.0)

24.5 (8.3–72.0)

Herpes Zoster

8.8 (3.8–20.6)

12.7 (6.7–24.1)

12.3 (6.0–25.4)

Diabetes mellitusb

9.0 (3.9–21.2)

4.4 (1.5–13.1)

5.6 (1.9–16.5)

Cataractb

9.2 (3.9–21.5)

9.1 (4.2–19.8)

7.5 (2.9–19.4)

Glaucomab

3.6 (1.0–13.0)

1.4 (0.3–8.2)

1.8 (0.3–10.2)

  1. aData are expressed as point estimates and 95% confidence intervals
  2. bThese data are based on open-ended questions about complications, Abbreviation: OMDS, Osame motor disability score