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Table 6 Incidence of steroid-related complications by steroid treatment status

From: Real-world clinical course of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Japan

  Patients with HAM/TSP without steroid therapy during the observation period (Untreated group, n = 185) Patients with HAM/TSP with at least once steroid therapy during the observation period (Steroid group, n = 225) Patients with HAM/TSP who had continued steroid therapy during the observation period (Continued steroid group, n = 181)
OMDS 1–4 46 (24.9%) 51 (22.7%) 39 (21.5%)
OMDS 5 54 (29.2%) 91 (40.4%) 71 (39.2%)
OMDS 6 34 (18.4%) 38 (16.9%) 34 (18.8%)
OMDS 7–13 51 (27.6%) 45 (20.0%) 37 (20.4%)
Steroid-related complications Incidence
per 1000 person-yearsa
Incidence
per 1000 person-yearsa
Incidence
per 1000 person-yearsa
Bone fracture 48.3 (33.0–70.8) 61.0 (45.1–82.5) 65.6 (47.4–90.8)
 OMDS 1–4 42.9 (18.3–100.5) 33.4 (14.2–78.1) 35.0 (13.6–90.1)
 OMDS 5 26.2 (10.2–67.3) 76.5 (50.0–116.9) 83.4 (52.8–131.9)
 OMDS 6 72.4 (36.7–142.9) 60.3 (29.2–124.5) 48.4 (20.7–113.2)
 OMDS 7–13 56.8 (29.9–107.9) 60.9 (32.0–115.7) 77.9 (41.0–148.0)
 Lower limb fracture 21.8 (12.5–38.1) 24.2 (15.1–38.7) 26.7 (16.2–44.0)
 OMDS 1–4 0.0 (0.0–30.5) 6.6 (1.2–37.6) 8.7 (1.5–49.2)
 OMDS 5 25.8 (10.0–66.4) 25.1 (12.1–51.7) c
 OMDS 6 35.6 (13.8–91.4) 8.4 (1.5–47.5) 0.0 (0.0–36.1)
 OMDS 7–13 25.4 (9.9–65.4) 51.8 (26.3–102.3) 65.6 (33.2–129.4)
 Compression fracture 16.1 (8.5–30.6) 25.4 (16.1–40.2) 28.1 (17.3–45.7)
 OMDS 1–4 8.4 (1.5–47.5) 13.1 (3.6–47.7) 17.1 (4.7–62.3)
 OMDS 5 0.0 (0.0–24.0) 28.3 (14.4–55.9) 26.8 (12.3–58.5)
 OMDS 6 35.5 (13.8–91.4) 42.4 (18.1–99.2) 47.5 (20.3–111.2)
 OMDS 7–13 23.8 (9.3–61.2) 19.4 (6.6–57.0) 24.5 (8.3–72.0)
Herpes Zoster 8.8 (3.8–20.6) 12.7 (6.7–24.1) 12.3 (6.0–25.4)
Diabetes mellitusb 9.0 (3.9–21.2) 4.4 (1.5–13.1) 5.6 (1.9–16.5)
Cataractb 9.2 (3.9–21.5) 9.1 (4.2–19.8) 7.5 (2.9–19.4)
Glaucomab 3.6 (1.0–13.0) 1.4 (0.3–8.2) 1.8 (0.3–10.2)
  1. aData are expressed as point estimates and 95% confidence intervals
  2. bThese data are based on open-ended questions about complications, Abbreviation: OMDS, Osame motor disability score