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Table 6 Studies assessing thyroid hormone status and thyroid cancer in adult GD1 patients

From: Endocrine and metabolic disorders in patients with Gaucher disease type 1: a review

Author (year)Study populationMain findings
Langeveld et al., 2007 [66]22 adult GD1 patients, assessed before and during ERTNormal thyroid hormone levels in 77% patients at baseline.
No correlations between serum levels of: 3,3′,5-triiodo-l-thyronine (T3), free thyroxine (fT4), 3,3′,5′-triiodo-l-thyronine (rT3) and baseline REE (kcal/kg per 24 h).
A decrease in fT4 and REE during ERT. No correlation between decrease in fT4 and T(3) and changes in REE.
Lo et al., 2010 [76]403 adult GD1 patients, treated and untreatedTwo cases of papillary thyroid carcinoma concomitant with haematological malignancies in splenectomised subjects.
  1. ERT enzyme replacement therapy; fT4 free thyroxine, GD1 Gaucher disease type 1; REE resting energy expenditure; rT3–3,3′,5′ triiodo-l-thyronine; SRT substrate reduction therapy