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Table 4 Studies assessing adopinectin, leptin and grelin in adult GD1 patients

From: Endocrine and metabolic disorders in patients with Gaucher disease type 1: a review

Author (year)Study populationMain findings
Doneda et al., 2015 [46]15 adult, ERT-treated GD1 patientsNo differences in median levels of ghrelin, leptin and adiponectin between patients and controls.
Lower adiponectin concentrations in patients with splenomegaly vs. subject without splenomegaly.
Inverse correlation between both ghrelin and
adiponectin levels and BMI, waist circumference
and TG. Positive correlation between both ghrelin and
adiponectin levels and HDL-c.
Inverse correlation between leptin and LDL-c and a direct correlation between leptin and BMI, waist circumference, enzyme dosage, TG, insulin, and HOMA-IR.
Langeveld et al., 2007 [57]28 adult GD1 patients (26 on ERT, 2 on SRT), assessed before and after several years of therapySignificantly lower serum adiponectin concentrations in untreated patients compared with healthy BMI-matched controls.
Post-ERT adiponectin levels increased significantly, but remained lower vs. those of BMI-matched controls
No correlation between adiponectin level and BMI in untreated GD1 patients
  1. BMI body mass index; ERT enzyme replacement therapy; GD1 Gaucher disease type 1; HDL-c high-density lipoprotein cholesterol; LDL low-density lipoprotein cholesterol; SRT substrate reduction therapy; TG triglycerides