|Author (year)||Study population||Main findings|
|Alfonso et al., 2003 ||70 adult GD patients (54 on ERT, 16 without treatment)||Increase of HDL-c (+ 38%) and apo A-I (+ 18%) levels in ERT-treated patients.|
No significant effect of ERT on LDL-c and apo B levels.
Decrease of plasma-apo E (− 32%) and HDL-apo E (− 26%) concentrations after ERT
|de Fost et al., 2008 ||40 adult GD1 patients (34 on ERT, 2 on STR, 4 untreated)||Significantly lower levels of HDL-c and ApoA1 and higher TG levels in patients vs. controls.|
No differences in cIMT between patients and controls.
|Puzo et al., 2010 ||26 adult GD1 patients treated with SRT for up to 36 months||Increase in plasma HDL-c and apoA-I in therapy-naive patients after SRT.|
Decrease in levels of TG, CRP concentrations, and TC/HDL-c ratios after 24 months of SRT.
No changes in HDL-c and apoA-I, or in the TC/HDL-c ratio in patients switched from ERT to SRT
|Stein et al., 2011 ||278 adult, GD1 patients, evaluated before and during ERT.||Significantly lower HDL-c in untreated GD1 subjects.|
A negative correlation between HDL-c chitotriosidase level, spleen and liver volume, GD severity score index.
A rise of initially low HDL-c towards normal after ERT
|Zimmermann et al., 2013 ||12 treatment-naive adult GD1 patients, evaluated before and after 3 years of ERT.||Pre-ERT: decreased HDL-c concentrations, increased LDL/HDL ratios (3.1 ± 0.7).|
Increase of HDL-c after 6 months of ERT.
Decrease of LDL/HDL ratio after 30 months of ERT.
Decrease of TG after 18 months of ERT.
Small dense LDL concentration increased constantly and was comparable to controls.
After 3 years of ERT: reduced HDL-C concentrations, however, mean concentrations significantly improved