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Fig. 3 | Orphanet Journal of Rare Diseases

Fig. 3

From: mTOR pathway in human cardiac hypertrophy caused by LEOPARD syndrome: a different role compared with animal models?

Fig. 3

Signaling activity of the mTOR complex 1 pathway examined by western blotting. LS, LEOPARD syndrome; SA, sarcomere mutated HCM; C, healthy controls. P indicates phosphorylated protein, and t indicates total protein. PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase (gene name PIK3CA, PIK3CB, PIK3CG, and PIK3CD); PDK1, phosphoinositide-dependent kinase 1 (gene name PDK1); Akt, protein kinase B (gene name Akt1); TSC2, tuberous sclerosis complex 2 (gene name TSC2); mTOR, mammalian target of rapamycin (gene name MTOR); 4E-BP-1, eukaryotic translation initiation factor 4E-binding protein 1 (gene name EIF4EBP1); S6K, ribosomal protein S6 kinase (gene name S6k); S6, ribosomal protein S6 (gene name RPS6); GAPDH, glyceraldehyde 3-phosphate dehydrogenase (gene name GAPDH), was used as a loading control

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172