Skip to main content

Table 4 Lipoproteins, markers of inflammation and oxidative stress in patients and healthy controls

From: The cardiovascular phenotype of adult patients with phenylketonuria

 

PKU patients

Control group

p-value

mean ± SD or median [IQR]

n

mean ± SD or median [IQR]

n

 

Lipids and Lipoproteins (mmol/l)

 Total Cholesterol

4.3 ± 0.6

23

3.8 ± 0.6

28

0.003

 LDLc

2.8 ± 0.7

23

2.6 ± 0.8

28

n.s.

 HDLc

1.4 ± 0.3

23

1.6 ± 0.3

28

0.032

 LDLc/HDLc

2.1 ± 0.5

23

1.7 ± 0.6

28

0.018

 ApoA1 (mg/ml)

2.1 ± 0.7

23

1.8 ± 0.3

16

n.s.

 HDL2c

0.6 ± 0.3

23

0.8 ± 0.2

28

0.009

 HDL3c

0.8 ± 0.1

23

0.8 ± 0.1

28

n.s.

 HDL2c/HDL3c

0.8 ± 0.3

23

1.1 ± 0.3

28

0.005

 Non-HDLc

2.9 ± 0.4

23

2.2 ± 0.6

28

< 0.001

 Triglycerides

1.3 ± 0.8

23

1.1 ± 0.6

28

n.s.

 Phospholipids

2.7 ± 0.6

23

2.6 ± 0.4

28

n.s.

Markers of  Inflammation (mg/l)

 SAA

6.7 [2.8–14.4]

22

2.9 [1.5–5.2]

27

0.010

 CRP

18.4 [7.3–83.3]

22

6.3 [2.0–42.1]

27

0.010

Markers of Oxidative Stress

 MDA (μg/ml)

0.33 [0.23–0.59]

23

0.23 [0.12–0.38]

27

0.027

 MPO (μg/ml)

0.68 [0.29–0.97]

19

0.89 [0.34–1.3]

26

n.s.

 3-NT (nmol/l)

1.8 [0.34–2.7]

22

1.7 [0.92–2.4]

28

n.s.