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Table 4 Lipoproteins, markers of inflammation and oxidative stress in patients and healthy controls

From: The cardiovascular phenotype of adult patients with phenylketonuria

  PKU patients Control group p-value
mean ± SD or median [IQR] n mean ± SD or median [IQR] n  
Lipids and Lipoproteins (mmol/l)
 Total Cholesterol 4.3 ± 0.6 23 3.8 ± 0.6 28 0.003
 LDLc 2.8 ± 0.7 23 2.6 ± 0.8 28 n.s.
 HDLc 1.4 ± 0.3 23 1.6 ± 0.3 28 0.032
 LDLc/HDLc 2.1 ± 0.5 23 1.7 ± 0.6 28 0.018
 ApoA1 (mg/ml) 2.1 ± 0.7 23 1.8 ± 0.3 16 n.s.
 HDL2c 0.6 ± 0.3 23 0.8 ± 0.2 28 0.009
 HDL3c 0.8 ± 0.1 23 0.8 ± 0.1 28 n.s.
 HDL2c/HDL3c 0.8 ± 0.3 23 1.1 ± 0.3 28 0.005
 Non-HDLc 2.9 ± 0.4 23 2.2 ± 0.6 28 < 0.001
 Triglycerides 1.3 ± 0.8 23 1.1 ± 0.6 28 n.s.
 Phospholipids 2.7 ± 0.6 23 2.6 ± 0.4 28 n.s.
Markers of  Inflammation (mg/l)
 SAA 6.7 [2.8–14.4] 22 2.9 [1.5–5.2] 27 0.010
 CRP 18.4 [7.3–83.3] 22 6.3 [2.0–42.1] 27 0.010
Markers of Oxidative Stress
 MDA (μg/ml) 0.33 [0.23–0.59] 23 0.23 [0.12–0.38] 27 0.027
 MPO (μg/ml) 0.68 [0.29–0.97] 19 0.89 [0.34–1.3] 26 n.s.
 3-NT (nmol/l) 1.8 [0.34–2.7] 22 1.7 [0.92–2.4] 28 n.s.