From: The cardiovascular phenotype of adult patients with phenylketonuria
PKU patients | Control group | p-value | |||
---|---|---|---|---|---|
mean ± SD or median [IQR] | n | mean ± SD or median [IQR] | n | ||
Lipids and Lipoproteins (mmol/l) | |||||
Total Cholesterol | 4.3 ± 0.6 | 23 | 3.8 ± 0.6 | 28 | 0.003 |
LDLc | 2.8 ± 0.7 | 23 | 2.6 ± 0.8 | 28 | n.s. |
HDLc | 1.4 ± 0.3 | 23 | 1.6 ± 0.3 | 28 | 0.032 |
LDLc/HDLc | 2.1 ± 0.5 | 23 | 1.7 ± 0.6 | 28 | 0.018 |
ApoA1 (mg/ml) | 2.1 ± 0.7 | 23 | 1.8 ± 0.3 | 16 | n.s. |
HDL2c | 0.6 ± 0.3 | 23 | 0.8 ± 0.2 | 28 | 0.009 |
HDL3c | 0.8 ± 0.1 | 23 | 0.8 ± 0.1 | 28 | n.s. |
HDL2c/HDL3c | 0.8 ± 0.3 | 23 | 1.1 ± 0.3 | 28 | 0.005 |
Non-HDLc | 2.9 ± 0.4 | 23 | 2.2 ± 0.6 | 28 | < 0.001 |
Triglycerides | 1.3 ± 0.8 | 23 | 1.1 ± 0.6 | 28 | n.s. |
Phospholipids | 2.7 ± 0.6 | 23 | 2.6 ± 0.4 | 28 | n.s. |
Markers of Inflammation (mg/l) | |||||
SAA | 6.7 [2.8–14.4] | 22 | 2.9 [1.5–5.2] | 27 | 0.010 |
CRP | 18.4 [7.3–83.3] | 22 | 6.3 [2.0–42.1] | 27 | 0.010 |
Markers of Oxidative Stress | |||||
MDA (μg/ml) | 0.33 [0.23–0.59] | 23 | 0.23 [0.12–0.38] | 27 | 0.027 |
MPO (μg/ml) | 0.68 [0.29–0.97] | 19 | 0.89 [0.34–1.3] | 26 | n.s. |
3-NT (nmol/l) | 1.8 [0.34–2.7] | 22 | 1.7 [0.92–2.4] | 28 | n.s. |