Table 4 Main neuroradiological findings over follow-up in 9 patients with HHH syndrome
From: Corticospinal tract damage in HHH syndrome: a metabolic cause of hereditary spastic paraplegia
Pt | Age at MRI assessment (yrs) | Brain atrophy | Spinal cord atrophy | ||
|---|---|---|---|---|---|
Supratentorial | Corpus callosum | Subtentorial | |||
1 | 40 | + | – | + | n.d. |
2 | 27 | + | – | – | n.d. |
34 | ++ | + | – | n.d. | |
36 | ++ | + | + | ++ | |
3 | 19 | ++ | ++ | – | +++ |
4 | 18 | + | + | + | n.d. |
23 | + | + | + | + | |
5 | 25 | ++ | + | – | n.d. |
34 | ++ | ++ | + | – | |
6 | 28 | ++ | + | + | n.d |
7 | 12 | – | – | – | – |
8 | 8 | – | – | – | – |
9 | 8 | – | – | + | – |