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Table 1 Annualized cost per patient

From: Haemophilia A: health and economic burden of a rare disease in Portugal

  Mild w/o inhibitors Moderate w/o inhibitors Severe w/o inhibitors Inhibitors Overall
Children
 Direct costs € 168 € 295 € 90,446 € 349,973 € 70,908
  Monitoring € 168 € 295 € 724 € 4,968 € 835
  Prophylaxis € 0 € 0 € 82,920 € 40,478 € 41,377
  ITI € 0 € 0 € 0 € 257,972 € 21,670
  Minor bleedings € 0 € 0 € 4,649 € 38,469 € 5,361
  Major bleedings € 0 € 0 € 243 € 8,086 € 791
 Orthopaedic surgeries € 0 € 0 € 1,910 € 0 € 875
  HIV co-infection € 0 € 0 € 0 € 0 € 0
 Indirect costsa € 0 € 376 € 2,347 € 3,286 € 1,379
  Unemployment € 0 € 0 € 0 € 0 € 0
  Early retirement € 0 € 0 € 0 € 0 € 0
 Work absence € 0 € 376 € 2,347 € 3,286 € 1,379
 Total cost € 168 € 670 € 92,793 € 35, 260 € 72,287
Adults
 Direct costs € 168 € 5,661 € 76,592 € 279,429 € 48,294
  Monitoring € 168 € 239 € 644 € 661 € 402
  Prophylaxis € 0 € 5,422 € 43,380 € 48,576 € 21,319
  ITI € 0 € 0 € 0 € 0 € 0
  Minor bleedings € 0 € 0 € 25,842 € 224,212 € 23,496
  Major bleedings € 0 € 0 € 3,759 € 4,923 € 1,812
 Orthopaedic surgeries € 0 € 0 € 1,910 € 0 € 775
  HIV co-infection € 0 € 0 € 1,056 € 1,056 € 490
  HCV co-infection € 0 € 0 € 0 € 0 € 0
 Indirect costs € 310 € 1,218 € 6,884 € 5,736 € 3,443
  Unemployment € 0 € 51 € 5,164 € 5,164 € 2,405
  Early retirement € 0 € 20 € 30 € 118 € 22
 Work absence € 310 € 1,148 € 1,690 € 454 € 1,016
 Total cost € 478 € 6,880 € 83,476 € 285,165 € 51,737
Overall
 Direct costs € 168 € 4,320 € 80,055 € 297,065 € 53,948
  Monitoring € 168 € 253 € 664 € 1,738 € 510
  Prophylaxis € 0 € 4,067 € 53,265 € 46,551 € 26,333
  ITI € 0 € 0 € 0 € 64,493 € 5,417
  Minor bleedings € 0 € 0 € 20,544 € 177,777 € 18,962
  Major bleedings € 0 € 0 € 2,880 € 5,714 € 1,557
 Orthopaedic surgeries € 0 € 0 € 1,910 € 0 € 800
  HIV co-infection € 0 € 0 € 792 € 792 € 368
 Indirect costs € 233 € 1,008 € 5,750 € 5,124 € 2,927
  Unemployment € 0 € 38 € 3,873 € 3,873 € 1,803
  Early retirement € 0 € 15 € 23 € 89 € 17
 Work absence € 233 € 955 € 1,854 € 1,162 € 1,107
 Total cost € 401 € ,5327 € 85,805 € 302,189 € 56,875
  1. aInformal caregivers