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Table 4 Metabolite ratios for the pediatric patients (#12 and #13) at different time points (with and without overload and with and without vitamin B2)

From: Diagnosis and phenotypic assessment of trimethylaminuria, and its treatment with riboflavin: 1H NMR spectroscopy and genetic testing

Metabolite ratio Patient #12 Time 0 with dietary overload Patient #12
3 months without dietary overload without vitamin B2
Patient #12
9 months with vitamin B2
Patient #13
Time 0 without dietary overload without vitamin B2
Patient #13
2 months with vitamin B2
Patient #13
3 months with vitamin B2
TMAO/Cr (mmol/mol) 1702 86 28 25.5 67.3 55.7
TMA/Cr (mmol/mol) 192 123 9 29.3 22.3 29
TMA/TMAO (mol/mol) 0.113 1.14 0.32 1.15 0.33 0.52
TMAO/(TMA + TMAO) (mol/mol) 0.90 0.411 0.76 0.54 0.75 0.66
  1. The normal ranges for healthy controls were TMAO/Cr ranging from 50 to 1000, TMA/Cr < 10, TMA/TMAO < 0.1 (reported by Chalmers et al. [5]) and TMAO/(TMA + TMAO) > 0.8 (reported by Eugène [4])