Skip to main content

Table 3 Mean [95% confidence interval] metabolite ratios for the adult patients (#1 to #11)

From: Diagnosis and phenotypic assessment of trimethylaminuria, and its treatment with riboflavin: 1H NMR spectroscopy and genetic testing

Metabolite ratio

Mean

95% confidence interval

P-value

Reference value

TMAO/Cr (mmol/mol)

65.5

42–89

2.10−6

50–1000

TMA/Cr (mmol/mol)

7.8

1–14

3.10−2

< 10

TMA/TMAO (mol/mol)

0.13

0.06–0.19

7.10−4

< 0.1

TMAO/TMA + TMAO (mol/mol)

0.90

0.85–0.94

2.10−16

> 0.8

  1. The normal ranges for healthy controls were TMAO/Cr ranging from 50 to 1000, TMA/Cr < 10, TMA/TMAO < 0.1 (reported by Chalmers et al. [5]) and TMAO/(TMA + TMAO) > 0.8 (reported by Eugène [4])
Back to article page

Orphanet Journal of Rare Diseases

ISSN: 1750-1172