Skip to main content

Table 3 Mean [95% confidence interval] metabolite ratios for the adult patients (#1 to #11)

From: Diagnosis and phenotypic assessment of trimethylaminuria, and its treatment with riboflavin: 1H NMR spectroscopy and genetic testing

Metabolite ratio Mean 95% confidence interval P-value Reference value
TMAO/Cr (mmol/mol) 65.5 42–89 2.10−6 50–1000
TMA/Cr (mmol/mol) 7.8 1–14 3.10−2 < 10
TMA/TMAO (mol/mol) 0.13 0.06–0.19 7.10−4 < 0.1
TMAO/TMA + TMAO (mol/mol) 0.90 0.85–0.94 2.10−16 > 0.8
  1. The normal ranges for healthy controls were TMAO/Cr ranging from 50 to 1000, TMA/Cr < 10, TMA/TMAO < 0.1 (reported by Chalmers et al. [5]) and TMAO/(TMA + TMAO) > 0.8 (reported by Eugène [4])