Fig. 4

Forest plot examining the association between PA and deletion size. OR and 95% CI of studies are shown. Pooled estimator is represented by the blue line diamond. Three studies were excluded a priori from this analysis: Wu (2013) because all the patients were selected from a Center for Cleft lip and palate and all had this phenotypic manifestation; Hwang (2014) and Mlynarski (2015) as neither of these studies evaluated PA phenotype. a Contrast of patients with AB deletion against grouped patients with AC and AD (AC-AD) deletion. Fernandez (2005) was also excluded a priori from this analysis, as they did not differentiate between AB and AC deletions. Finally, one study was excluded during the statistical analysis, Carlson (1997), because it had all events in both arms, thus an OR of 1 that does not provide useful information to the analysis. b Contrast of patients with AD deletion against grouped patients with AB and AC (AB-AC) deletion. Two studies were excluded during the statistical analysis, Carlson (1997) and Fernandez (2005) because they both had all events in both arms, thus an OR of 1 that does not provide useful information to the analysis