Fig. 7

Enhanced neutrophil recruitment in patients with SAPHO syndrome a Neutrophils in peripheral blood are primed by stimuli. Active transcription and expression of receptors or other molecules are then initiated, while the endothelial cells present chemokines which mediate neutrophil arrest, rolling, adhesion, crawling and migration. Differentially expressed genes in SAPHO group are marked with a red arrow. b Expression levels of up-regulated genes participating in the process of neutrophil recruitment based on RNA-Seq data, p value was calculated by Student t-test