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Table 3 History of manifestations of HPP in pediatric patients

From: Burden of disease in pediatric patients with hypophosphatasia: results from the HPP Impact Patient Survey and the HPP Outcomes Study Telephone interview

Manifestation Patients, n (%)
Pain (any HPP-related pain) 51/ 59 (86.4)
 Joint paina 27/44 (61.4)
 Bone paina 23/44 (52.3)
 Muscle paina 9/44 (20.5)
Joint and muscle manifestations
 Muscle weakness 41/58 (70.7)
 Extremely flexible joints 21/57 (36.8)
Developmental manifestations
 Difficulty gaining weight 38/59 (64.4)
 Delayed walking 34/58 (58.6)
 Short stature 28/58 (48.3)
 Seizuresa 4/44 (9.1)
Skeletal abnormalities
 Bowing of legs or knock knees 34/59 (57.6)
 Abnormally shaped chest 32/59 (54.2)
 Abnormally shaped head 30/57 (52.6)
 Knock knees 23/59 (39.0)
 Bowing of legs 22/59 (37.3)
 Bowing of arms 12/59 (20.3)
Respiratory manifestations
 Pneumonia 16/59 (27.1)
 Difficulty breathinga 11/44 (25.0)
Fractures
 Non-vertebral fracturea 6/44 (13.6)
 Pseudofracturea 3/44 (6.8)
 Non-healing fracturea 1/44 (2.3)
  1. Data are expressed as the number of patients who reported a particular HPP manifestation divided by the total number of patients who responded to the question. All manifestations are captured by both the HIPS and HOST unless stated otherwise. Bold italicized numbers indicate the three most frequent symptoms
  2. a Assessed by HIPS only (n = 44)
  3. HIPS Hypophosphatasia Impact Patient Survey, HOST Hypophosphatasia Outcomes Study Telephone interview, HPP hypophosphatasia