Burden of disease in pediatric patients with hypophosphatasia: results from the HPP Impact Patient Survey and the HPP Outcomes Study Telephone interview

Table 3 History of manifestations of HPP in pediatric patients

Manifestation	Patients, n (%)
Pain (any HPP-related pain)	*51/ 59 (86.4)*
Joint pain^a	27/44 (61.4)
Bone pain^a	23/44 (52.3)
Muscle pain^a	9/44 (20.5)
Joint and muscle manifestations
Muscle weakness	*41/58 (70.7)*
Extremely flexible joints	21/57 (36.8)
Developmental manifestations
Difficulty gaining weight	*38/59 (64.4)*
Delayed walking	34/58 (58.6)
Short stature	28/58 (48.3)
Seizures^a	4/44 (9.1)
Skeletal abnormalities
Bowing of legs or knock knees	34/59 (57.6)
Abnormally shaped chest	32/59 (54.2)
Abnormally shaped head	30/57 (52.6)
Knock knees	23/59 (39.0)
Bowing of legs	22/59 (37.3)
Bowing of arms	12/59 (20.3)
Respiratory manifestations
Pneumonia	16/59 (27.1)
Difficulty breathing^a	11/44 (25.0)
Fractures
Non-vertebral fracture^a	6/44 (13.6)
Pseudofracture^a	3/44 (6.8)
Non-healing fracture^a	1/44 (2.3)

Data are expressed as the number of patients who reported a particular HPP manifestation divided by the total number of patients who responded to the question. All manifestations are captured by both the HIPS and HOST unless stated otherwise. Bold italicized numbers indicate the three most frequent symptoms
^a Assessed by HIPS only (n = 44)
HIPS Hypophosphatasia Impact Patient Survey, HOST Hypophosphatasia Outcomes Study Telephone interview, HPP hypophosphatasia

ISSN: 1750-1172