Fig. 3
From: Angiogenesis induction in Buerger's disease: a disease management double-edged sword?
Intimal fibrosis thickening instead of proliferation of endothelial cells, inflammatory thrombus and NETosis formation inside preserved vessels and organised thrombus in a TAO patient who received no treatment for many years. a PAS staining. X10 objective lense. Perivascular infiltration of inflammatory cells and the preserved vascular structure of a small artery with early-stage thrombus formation. b PAS staining. X40 objective lense Diffuse intimal thiceking with infiltration of inflamamtory cells in the intima layer. c H&E staining. X40 objective lense. Infiltration of inflammatory cells in all layers of the vessel. d PAS staining. X40 objective lense Organized thrombus with recanalization. The arrow shows basal membrane of intima. e IHC for CD31. X40 objective lense. According to the IHC, the intima thickening was not due to the proliferation of endothelial cells. f IHC for Ki67. X40 objective lens. Negative results support that intima thickening was not due to any active cell proliferation