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Table 8 ATC code and subcode of the top 50 most commonly prescribed agents in the late-diagnosed PKU populationa

From: Clinical burden of illness in patients with phenylketonuria (PKU) and associated comorbidities - a retrospective study of German health insurance claims data

ATC code or subcode Category or subcategory Late-diagnosed PKU patients (n = 216)
%
Control group (n = 2,161)
%
PR (95% CI)
C Cardiovascular system 67.1 60.6 1.11 (1.00, 1.22)
C09 Agents acting on the renin-angiotensin system 47.7 44.7 1.07 (0.92, 1.24)
C07 Beta blocking agents 39.4 32.6 1.21 (1.01, 1.44) b
C10 Lipid modifying agents 32.4 22.5 1.44 (1.17, 1.77) b
C03 Diuretics 25.5 17.9 1.42 (1.11, 1.82) b
C08 Calcium channel blockers 19.9 15.1 1.32 (0.99, 1.76)
C01 Cardiac therapy 10.2 5.4 1.90 (1.23, 2.93) b
A Alimentary tract and metabolism 52.3 41.3 1.27 (1.10, 1.45) b
A02 Drugs for acid related disorders 39.4 28.3 1.39 (1.16, 1.66) b
A10 Antidiabetics 15.7 13.4 1.17 (0.85, 1.63)
N Nervous system 50.5 36.3 1.39 (1.20, 1.60) b
N02 Analgesics 33.3 24.8 1.35 (1.10, 1.65) b
N06 Psychoanaleptics 19.4 12.0 1.62 (1.20, 2.17) b
M Musculo-skeletal system 42.6 39.2 1.09 (0.92, 1.28)
M01 Antiinflammatory and antirheumatic products 32.9 31.9 1.03 (0.84, 1.26)
M04 Antigout preparations 13.0 8.3 1.56 (1.08, 2.27) b
M05 Drugs for treatment of bone diseases 3.7 2.6 1.43 (0.69, 2.96)
J Antiinfectives for systemic use 38.0 33.5 1.13 (0.95, 1.36)
J01 Antibacterials for systemic use 36.1 32.0 1.13 (0.93, 1.36)
H Systemic hormonal preparations, excl. Sexual hormones and insulins 30.6 26.5 1.15 (0.93, 1.43)
H03 Thyroid therapy 19.9 19.7 1.01 (0.76, 1.34)
H02 Corticosteroids for systemic use 13.0 9.4 1.37 (0.95, 1.99)
D Dermatologicals 28.7 18.8 1.53 (1.22, 1.92) b
D07 Corticosteroid, dermatological preparations 16.2 11.2 1.45 (1.05, 2.01) b
D01 Antimycotics for dermatological use 7.9 4.7 1.68 (1.03, 2.76) b
R Respiratory system 25.9 17.6 1.47 (1.15, 1.87) b
R03 Drugs for obstructive airway diseases 18.1 11.8 1.53 (1.13, 2.08) b
B Blood and blood forming organs 22.7 22.6 1.00 (0.77, 1.30)
B01 Antithrombotic agents 20.4 19.7 1.03 (0.78, 1.36)
G Genitourinary system and sexual hormones 21.3 14.4 1.47 (1.12, 1.94) b
G04 Urologicals 12.0 8.6 1.40 (0.95, 2.06)
G01 Gynecological antiinfectives and antiseptics 3.2 0.6 5.38 (2.17, 13.35) b
S Sensory organs 10.6 14.4 0.74 (0.50, 1.11)
  1. aData are only shown for subcodes that were prescribed in > 10% of PKU patients or those that were significant vs the control population. ATC category totals may not add up because subcategories with < 5 patients in the PKU group have been excluded from the table, but may still count to the total for the ATC class of drug
  2. bATC codes that had a significant PR vs the control population
  3. One letter ATC codes (e.g. Dermatologicals, Cardiovascular system) are shown in bold