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Table 8 ATC code and subcode of the top 50 most commonly prescribed agents in the late-diagnosed PKU populationa

From: Clinical burden of illness in patients with phenylketonuria (PKU) and associated comorbidities - a retrospective study of German health insurance claims data

ATC code or subcode

Category or subcategory

Late-diagnosed PKU patients (n = 216)

%

Control group (n = 2,161)

%

PR (95% CI)

C

Cardiovascular system

67.1

60.6

1.11 (1.00, 1.22)

C09

Agents acting on the renin-angiotensin system

47.7

44.7

1.07 (0.92, 1.24)

C07

Beta blocking agents

39.4

32.6

1.21 (1.01, 1.44) b

C10

Lipid modifying agents

32.4

22.5

1.44 (1.17, 1.77) b

C03

Diuretics

25.5

17.9

1.42 (1.11, 1.82) b

C08

Calcium channel blockers

19.9

15.1

1.32 (0.99, 1.76)

C01

Cardiac therapy

10.2

5.4

1.90 (1.23, 2.93) b

A

Alimentary tract and metabolism

52.3

41.3

1.27 (1.10, 1.45) b

A02

Drugs for acid related disorders

39.4

28.3

1.39 (1.16, 1.66) b

A10

Antidiabetics

15.7

13.4

1.17 (0.85, 1.63)

N

Nervous system

50.5

36.3

1.39 (1.20, 1.60) b

N02

Analgesics

33.3

24.8

1.35 (1.10, 1.65) b

N06

Psychoanaleptics

19.4

12.0

1.62 (1.20, 2.17) b

M

Musculo-skeletal system

42.6

39.2

1.09 (0.92, 1.28)

M01

Antiinflammatory and antirheumatic products

32.9

31.9

1.03 (0.84, 1.26)

M04

Antigout preparations

13.0

8.3

1.56 (1.08, 2.27) b

M05

Drugs for treatment of bone diseases

3.7

2.6

1.43 (0.69, 2.96)

J

Antiinfectives for systemic use

38.0

33.5

1.13 (0.95, 1.36)

J01

Antibacterials for systemic use

36.1

32.0

1.13 (0.93, 1.36)

H

Systemic hormonal preparations, excl. Sexual hormones and insulins

30.6

26.5

1.15 (0.93, 1.43)

H03

Thyroid therapy

19.9

19.7

1.01 (0.76, 1.34)

H02

Corticosteroids for systemic use

13.0

9.4

1.37 (0.95, 1.99)

D

Dermatologicals

28.7

18.8

1.53 (1.22, 1.92) b

D07

Corticosteroid, dermatological preparations

16.2

11.2

1.45 (1.05, 2.01) b

D01

Antimycotics for dermatological use

7.9

4.7

1.68 (1.03, 2.76) b

R

Respiratory system

25.9

17.6

1.47 (1.15, 1.87) b

R03

Drugs for obstructive airway diseases

18.1

11.8

1.53 (1.13, 2.08) b

B

Blood and blood forming organs

22.7

22.6

1.00 (0.77, 1.30)

B01

Antithrombotic agents

20.4

19.7

1.03 (0.78, 1.36)

G

Genitourinary system and sexual hormones

21.3

14.4

1.47 (1.12, 1.94) b

G04

Urologicals

12.0

8.6

1.40 (0.95, 2.06)

G01

Gynecological antiinfectives and antiseptics

3.2

0.6

5.38 (2.17, 13.35) b

S

Sensory organs

10.6

14.4

0.74 (0.50, 1.11)

  1. aData are only shown for subcodes that were prescribed in > 10% of PKU patients or those that were significant vs the control population. ATC category totals may not add up because subcategories with < 5 patients in the PKU group have been excluded from the table, but may still count to the total for the ATC class of drug
  2. bATC codes that had a significant PR vs the control population
  3. One letter ATC codes (e.g. Dermatologicals, Cardiovascular system) are shown in bold
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172