Table 7 Comorbidity profile of late-diagnosed adult PKU patients in 2015 in Germany
ICD-10-GM code | Description | Late-diagnosed PKU patients (n = 216) % | Control group (n = 2,160) % | PR (95% CI) |
|---|---|---|---|---|
I10 | Essential (primary) hypertension | 61.1 | 58.4 | 1.05 (0.94, 1.17) |
E78 | Disorders of lipoprotein metabolism and other lipidemias | 52.3 | 40.4 | 1.30 (1.13, 1.49) a |
M54 | Dorsalgia | 42.1 | 36.1 | 1.17 (0.99, 1.38) |
H52 | Disorders of refraction and accommodation | 38.0 | 33.1 | 1.15 (0.96, 1.37) |
Z12 | Encounter for screening for malignant neoplasms | 28.2 | 30.0 | 0.94 (0.75, 1.18) |
I25 | Chronic ischemic heart disease | 25.9 | 15.6 | 1.67 (1.30, 2.13) a |
E11 | Type 2 diabetes mellitus | 25.5 | 19.6 | 1.30 (1.02, 1.65) a |
Z25 | Need for immunization against other single viral diseases | 22.2 | 20.4 | 1.09 (0.84, 1.42) |
M17 | Osteoarthritis of knee | 21.3 | 17.2 | 1.24 (0.94, 1.63) |
Z00 | Encounter for general exam without complaint, suspected or reported dx | 20.8 | 20.2 | 1.03 (0.79, 1.36) |
N95 | Menopausal and other perimenopausal disorders | 20.4 | 14.5 | 1.40 (1.06, 1.86) a |
E04 | Other nontoxic goiter | 19.9 | 14.7 | 1.35 (1.02, 1.80) a |
M47 | Spondylosis | 19.4 | 18.8 | 1.03 (0.78, 1.37) |
E66 | Overweight and obesity | 19.0 | 14.2 | 1.34 (0.99, 1.79) |
F32 | Major depressive disorder, single episode | 19.0 | 15.8 | 1.20 (0.90, 1.61) |
M53 | Other and unspecified dorsopathies, not elsewhere classified | 19.0 | 12.6 | 1.51 (1.12, 2.03) a |
Z01 | Encounter for other specified exam without complaint, suspected or reported dx | 18.5 | 12.9 | 1.43 (1.06, 1.94) a |
E14 | Unspecified diabetes mellitus | 18.5 | 10.7 | 1.73 (1.28, 2.35) a |
E79 | Disorders of purine and pyrimidine metabolism | 17.6 | 11.1 | 1.59 (1.16, 2.17) a |
N39 | Other disorders of urinary system | 17.6 | 12.5 | 1.40 (1.03, 1.91) a |
Z92 | Personal history of medical treatment | 17.1 | 13.0 | 1.32 (0.97, 1.81) |
F45 | Somatoform disorders | 17.1 | 14.3 | 1.20 (0.88, 1.64) |
J44 | Other chronic obstructive pulmonary disease | 16.2 | 8.2 | 1.97 (1.41, 2.75) a |
J06 | Acute upper respiratory infections of multiple and unspecified sites | 15.7 | 12.2 | 1.29 (0.93, 1.79) |
K29 | Gastritis and duodenitis | 15.7 | 11.1 | 1.42 (1.02, 1.98) a |
R42 | Dizziness and giddiness | 14.8 | 8.3 | 1.79 (1.26, 2.53) a |
I83 | Varicose veins of lower extremities | 14.8 | 13.0 | 1.14 (0.82, 1.60) |
Z96 | Presence of other functional implants | 14.4 | 14.7 | 0.97 (0.69, 1.37) |
N89 | Other noninflammatory disorders of vagina | 14.4 | 10.6 | 1.35 (0.96, 1.92) |
M19 | Other and unspecified osteoarthritis | 14.4 | 10.1 | 1.42 (1.00, 2.01) |
H35 | Other retinal disorders | 13.9 | 11.3 | 1.23 (0.86, 1.75) |
L30 | Other and unspecified dermatitis | 13.9 | 9.0 | 1.54 (1.08, 2.20) a |
I70 | Atherosclerosis | 13.9 | 7.6 | 1.82 (1.26, 2.61) a |
J45 | Asthma | 13.4 | 6.9 | 1.93 (1.33, 2.81) a |
I50 | Heart failure | 13.4 | 8.3 | 1.61 (1.12, 2.32) a |
M21 | Other acquired deformities of limbs | 13.0 | 5.0 | 2.59 (1.75, 3.83) a |
E03 | Other hypothyroidism | 13.0 | 10.7 | 1.21 (0.84, 1.75) |
N18 | Chronic kidney disease | 13.0 | 7.9 | 1.64 (1.13, 2.38) a |
N40 | Enlarged prostate | 13.0 | 12.3 | 1.06 (0.73, 1.52) |
K76 | Other diseases of liver | 12.5 | 10.6 | 1.18 (0.82, 1.72) |
M16 | Osteoarthritis of hip | 12.5 | 8.9 | 1.41 (0.96, 2.05) |
H25 | Age-related cataract | 12.5 | 11.2 | 1.12 (0.77, 1.62) |
D22 | Melanocytic nevi | 12.5 | 9.4 | 1.34 (0.92, 1.95) |
I49 | Other cardiac arrhythmias | 12.0 | 10.0 | 1.20 (0.82, 1.76) |
Z95 | Presence of cardiac and vascular implants and grafts | 12.0 | 8.1 | 1.48 (1.00, 2.18) |
M51 | Thoracic, thoracolumbar, and lumbosacral intervertebral disc disorders | 11.6 | 12.8 | 0.91 (0.62, 1.33) |
R10 | Abdominal and pelvic pain | 11.6 | 10.1 | 1.14 (0.77, 1.69) |
M42 | Spinal osteochondrosis | 11.6 | 8.5 | 1.36 (0.92, 2.01) |
H61 | Other disorders of external ear | 11.6 | 10.5 | 1.11 (0.75, 1.63) |