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Table 7 Comorbidity profile of late-diagnosed adult PKU patients in 2015 in Germany

From: Clinical burden of illness in patients with phenylketonuria (PKU) and associated comorbidities - a retrospective study of German health insurance claims data

ICD-10-GM code Description Late-diagnosed PKU patients (n = 216)
%
Control group (n = 2,160)
%
PR (95% CI)
I10 Essential (primary) hypertension 61.1 58.4 1.05 (0.94, 1.17)
E78 Disorders of lipoprotein metabolism and other lipidemias 52.3 40.4 1.30 (1.13, 1.49) a
M54 Dorsalgia 42.1 36.1 1.17 (0.99, 1.38)
H52 Disorders of refraction and accommodation 38.0 33.1 1.15 (0.96, 1.37)
Z12 Encounter for screening for malignant neoplasms 28.2 30.0 0.94 (0.75, 1.18)
I25 Chronic ischemic heart disease 25.9 15.6 1.67 (1.30, 2.13) a
E11 Type 2 diabetes mellitus 25.5 19.6 1.30 (1.02, 1.65) a
Z25 Need for immunization against other single viral diseases 22.2 20.4 1.09 (0.84, 1.42)
M17 Osteoarthritis of knee 21.3 17.2 1.24 (0.94, 1.63)
Z00 Encounter for general exam without complaint, suspected or reported dx 20.8 20.2 1.03 (0.79, 1.36)
N95 Menopausal and other perimenopausal disorders 20.4 14.5 1.40 (1.06, 1.86) a
E04 Other nontoxic goiter 19.9 14.7 1.35 (1.02, 1.80) a
M47 Spondylosis 19.4 18.8 1.03 (0.78, 1.37)
E66 Overweight and obesity 19.0 14.2 1.34 (0.99, 1.79)
F32 Major depressive disorder, single episode 19.0 15.8 1.20 (0.90, 1.61)
M53 Other and unspecified dorsopathies, not elsewhere classified 19.0 12.6 1.51 (1.12, 2.03) a
Z01 Encounter for other specified exam without complaint, suspected or reported dx 18.5 12.9 1.43 (1.06, 1.94) a
E14 Unspecified diabetes mellitus 18.5 10.7 1.73 (1.28, 2.35) a
E79 Disorders of purine and pyrimidine metabolism 17.6 11.1 1.59 (1.16, 2.17) a
N39 Other disorders of urinary system 17.6 12.5 1.40 (1.03, 1.91) a
Z92 Personal history of medical treatment 17.1 13.0 1.32 (0.97, 1.81)
F45 Somatoform disorders 17.1 14.3 1.20 (0.88, 1.64)
J44 Other chronic obstructive pulmonary disease 16.2 8.2 1.97 (1.41, 2.75) a
J06 Acute upper respiratory infections of multiple and unspecified sites 15.7 12.2 1.29 (0.93, 1.79)
K29 Gastritis and duodenitis 15.7 11.1 1.42 (1.02, 1.98) a
R42 Dizziness and giddiness 14.8 8.3 1.79 (1.26, 2.53) a
I83 Varicose veins of lower extremities 14.8 13.0 1.14 (0.82, 1.60)
Z96 Presence of other functional implants 14.4 14.7 0.97 (0.69, 1.37)
N89 Other noninflammatory disorders of vagina 14.4 10.6 1.35 (0.96, 1.92)
M19 Other and unspecified osteoarthritis 14.4 10.1 1.42 (1.00, 2.01)
H35 Other retinal disorders 13.9 11.3 1.23 (0.86, 1.75)
L30 Other and unspecified dermatitis 13.9 9.0 1.54 (1.08, 2.20) a
I70 Atherosclerosis 13.9 7.6 1.82 (1.26, 2.61) a
J45 Asthma 13.4 6.9 1.93 (1.33, 2.81) a
I50 Heart failure 13.4 8.3 1.61 (1.12, 2.32) a
M21 Other acquired deformities of limbs 13.0 5.0 2.59 (1.75, 3.83) a
E03 Other hypothyroidism 13.0 10.7 1.21 (0.84, 1.75)
N18 Chronic kidney disease 13.0 7.9 1.64 (1.13, 2.38) a
N40 Enlarged prostate 13.0 12.3 1.06 (0.73, 1.52)
K76 Other diseases of liver 12.5 10.6 1.18 (0.82, 1.72)
M16 Osteoarthritis of hip 12.5 8.9 1.41 (0.96, 2.05)
H25 Age-related cataract 12.5 11.2 1.12 (0.77, 1.62)
D22 Melanocytic nevi 12.5 9.4 1.34 (0.92, 1.95)
I49 Other cardiac arrhythmias 12.0 10.0 1.20 (0.82, 1.76)
Z95 Presence of cardiac and vascular implants and grafts 12.0 8.1 1.48 (1.00, 2.18)
M51 Thoracic, thoracolumbar, and lumbosacral intervertebral disc disorders 11.6 12.8 0.91 (0.62, 1.33)
R10 Abdominal and pelvic pain 11.6 10.1 1.14 (0.77, 1.69)
M42 Spinal osteochondrosis 11.6 8.5 1.36 (0.92, 2.01)
H61 Other disorders of external ear 11.6 10.5 1.11 (0.75, 1.63)
  1. aComorbidities that had a significant PR vs the control population