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Table 6 Top 50 most commonly prescribed ATC codes in the early-diagnosed PKU populationa

From: Clinical burden of illness in patients with phenylketonuria (PKU) and associated comorbidities - a retrospective study of German health insurance claims data

ATC code or subcode Category or subcategory Early-diagnosed PKU patients (n = 161)
%
Control group (n = 1,610)
%
PR (95% CI)
J Antiinfectives for systemic use 34.8 34.7 1.00 (0.80, 1.25)
J01 Antibacterials for systemic use 32.9 33.9 0.97 (0.77, 1.22)
N Nervous system 26.7 17.8 1.50 (1.14, 1.98) b
N06 Psychoanaleptics 14.3 6.1 2.35 (1.54, 3.59) b
N02 Analgesics 12.4 11.3 1.10 (0.71, 1.69)
N05 Psycholeptics 8.7 2.2 3.89 (2.14, 7.06) b
N03 Antiepileptics 3.7 0.7 5.00 (1.90, 13.14) b
M Musculo-skeletal system 25.5 22.5 1.13 (0.86, 1.50)
M01 Antiinflammatory and antirheumatic products 24.8 21.6 1.15 (0.86, 1.53)
A Alimentary tract and metabolism 24.8 14.0 1.78 (1.32, 2.39) b
A02 Drugs for acid related disorders 16.1 9.3 1.73 (1.18, 2.54) b
A11 Vitamins 5.6 0.6 9.00 (3.71, 21.83) b
H Systemic hormonal preparations, excl. Sexual hormones and insulins 16.8 12.7 1.32 (0.91, 1.90) b
H03 Thyroid therapy 12.4 9.4 1.32 (0.86, 2.05)
H02 Corticosteroids for systemic use 6.8 3.4 2.00 (1.07, 3.74) b
R Respiratory system 15.5 15.1 1.03 (0.70, 1.50)
D Dermatologicals 13.0 11.3 1.15 (0.76, 1.76)
C Cardiovascular system 12.4 6.3 1.98 (1.26, 3.11) b
C03 Diuretics 3.1 0.3 10.00 (2.93, 34.18) b
G Genitourinary system and sexual hormones 11.8 7.7 1.53 (0.97, 2.41)
B Blood and blood forming organs 7.5 3.5 2.11 (1.15, 3.84) b
L Antineoplastic and immunomodulating agents 4.3 1.6 2.80 (1.23, 6.37) b
  1. aData are only shown for subcodes that were prescribed in > 10% of PKU patients or those that were significant vs the control population. ATC category totals may not add up because subcategories with < 5 patients in the PKU group have been excluded from the table, but may still count to the total for the ATC class of drug
  2. bATC codes that had a significant PR vs the control population
  3. One letter ATC codes (e.g. Dermatologicals, Cardiovascular system) are shown in bold