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Table 4 ATC codes of the top 50 most commonly prescribed agents in the PKU populationa

From: Clinical burden of illness in patients with phenylketonuria (PKU) and associated comorbidities - a retrospective study of German health insurance claims data

ATC code or subcode Category or subcategory PKU patients (n = 377)
%
Control group (n = 3,770)
%
PR (95% CI)
C Cardiovascular system 43.8 37.4 1.17 (1.04, 1.32) b
C09 Agents acting on the renin-angiotensin system 30.0 27.0 1.11 (0.94, 1.31)
C07 Beta blocking agents 24.9 19.9 1.25 (1.04, 1.51) b
C10 Lipid modifying agents 19.4 13.1 1.48 (1.19, 1.85) b
C03 Diuretics 15.9 10.4 1.53 (1.19, 1.97) b
C08 Calcium channel blockers 12.5 8.9 1.40 (1.05, 1.86) b
C01 Cardiac therapy 6.1 3.1 1.95 (1.26, 3.01) b
A Alimentary tract and metabolism 40.6 29.6 1.37 (1.20, 1.56) b
A02 Drugs for acid related disorders 29.4 20.2 1.46 (1.23, 1.72) b
A11 Vitamins 4.5 2.0 2.27 (1.35, 3.80) b
A12 Minerals 3.7 1.3 2.86 (1.59, 5.13) b
N Nervous system 40.3 28.4 1.42 (1.24, 1.62) b
N02 Analgesics 24.4 19.0 1.28 (1.06, 1.55) b
N06 Psychoanaleptics 17.2 9.5 1.82 (1.43, 2.31) b
N05 Psycholeptics 8.8 5.4 1.62 (1.14, 2.30) b
N03 Antiepileptics 5.3 2.9 1.82 (1.14, 2.89) b
N07 Other nervous system drugs 2.7 1.3 2.08 (1.06, 4.08) b
J Antiinfectives for systemic use 36.6 34.0 1.08 (0.94, 1.24)
J01 Antibacterials for systemic use 34.7 32.8 1.06 (0.92, 1.23)
J07 Vaccines 1.9 0.3 6.36 (2.48, 16.32) b
M Musculo-skeletal system 35.3 32.0 1.10 (0.95, 1.27)
M01 Antiinflammatory and antirheumatic products 29.4 27.5 1.07 (0.91, 1.26)
M04 Antigout preparations 7.7 4.9 1.58 (1.09, 2.31) b
H Systemic hormonal preparations, excl. Sexual hormones and insulins 24.7 20.6 1.20 (0.99, 1.44)
H03 Thyroid therapy 16.7 15.3 1.09 (0.86, 1.39)
H02 Corticosteroids for systemic use 10.3 6.9 1.51 (1.09, 2.07) b
D Dermatologicals 22.0 15.6 1.41 (1.15, 1.73) b
D07 Corticosteroid, dermatological preparations 12.5 9.0 1.39 (1.04, 1.85) b
D01 Antimycotics for dermatological use 5.6 3.5 1.58 (1.01, 2.47) b
R Respiratory system 21.5 16.6 1.30 (1.06, 1.59) b
R03 Drugs for obstructive airway diseases 13.0 9.8 1.32 (1.00, 1.74)
G Genitourinary system and sexual hormones 17.2 11.6 1.49 (1.17, 1.89) b
G01 Gynecological antiinfectives and antiseptics 3.2 1.4 2.31 (1.24, 4.28) b
B Blood and blood forming organs 16.2 14.5 1.12 (0.88, 1.42)
B01 Antithrombotic agents 13.3 12.0 1.10 (0.84, 1.45)
S Sensory organs 8.8 11.4 0.77 (0.55, 1.08)
  1. aData are only shown for subcodes that were prescribed in > 10% of PKU patients or those that were significant vs the control population. ATC category totals may not add up because subcategories with < 5 patients in the PKU group have been excluded from the table, but may still count to the total for the ATC class of drug
  2. bATC codes that had a significant PR vs the control population
  3. One letter ATC codes (e.g. Dermatologicals, Cardiovascular system) are shown in bold