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Table 4 ATC codes of the top 50 most commonly prescribed agents in the PKU populationa

From: Clinical burden of illness in patients with phenylketonuria (PKU) and associated comorbidities - a retrospective study of German health insurance claims data

ATC code or subcode

Category or subcategory

PKU patients (n = 377)

%

Control group (n = 3,770)

%

PR (95% CI)

C

Cardiovascular system

43.8

37.4

1.17 (1.04, 1.32) b

C09

Agents acting on the renin-angiotensin system

30.0

27.0

1.11 (0.94, 1.31)

C07

Beta blocking agents

24.9

19.9

1.25 (1.04, 1.51) b

C10

Lipid modifying agents

19.4

13.1

1.48 (1.19, 1.85) b

C03

Diuretics

15.9

10.4

1.53 (1.19, 1.97) b

C08

Calcium channel blockers

12.5

8.9

1.40 (1.05, 1.86) b

C01

Cardiac therapy

6.1

3.1

1.95 (1.26, 3.01) b

A

Alimentary tract and metabolism

40.6

29.6

1.37 (1.20, 1.56) b

A02

Drugs for acid related disorders

29.4

20.2

1.46 (1.23, 1.72) b

A11

Vitamins

4.5

2.0

2.27 (1.35, 3.80) b

A12

Minerals

3.7

1.3

2.86 (1.59, 5.13) b

N

Nervous system

40.3

28.4

1.42 (1.24, 1.62) b

N02

Analgesics

24.4

19.0

1.28 (1.06, 1.55) b

N06

Psychoanaleptics

17.2

9.5

1.82 (1.43, 2.31) b

N05

Psycholeptics

8.8

5.4

1.62 (1.14, 2.30) b

N03

Antiepileptics

5.3

2.9

1.82 (1.14, 2.89) b

N07

Other nervous system drugs

2.7

1.3

2.08 (1.06, 4.08) b

J

Antiinfectives for systemic use

36.6

34.0

1.08 (0.94, 1.24)

J01

Antibacterials for systemic use

34.7

32.8

1.06 (0.92, 1.23)

J07

Vaccines

1.9

0.3

6.36 (2.48, 16.32) b

M

Musculo-skeletal system

35.3

32.0

1.10 (0.95, 1.27)

M01

Antiinflammatory and antirheumatic products

29.4

27.5

1.07 (0.91, 1.26)

M04

Antigout preparations

7.7

4.9

1.58 (1.09, 2.31) b

H

Systemic hormonal preparations, excl. Sexual hormones and insulins

24.7

20.6

1.20 (0.99, 1.44)

H03

Thyroid therapy

16.7

15.3

1.09 (0.86, 1.39)

H02

Corticosteroids for systemic use

10.3

6.9

1.51 (1.09, 2.07) b

D

Dermatologicals

22.0

15.6

1.41 (1.15, 1.73) b

D07

Corticosteroid, dermatological preparations

12.5

9.0

1.39 (1.04, 1.85) b

D01

Antimycotics for dermatological use

5.6

3.5

1.58 (1.01, 2.47) b

R

Respiratory system

21.5

16.6

1.30 (1.06, 1.59) b

R03

Drugs for obstructive airway diseases

13.0

9.8

1.32 (1.00, 1.74)

G

Genitourinary system and sexual hormones

17.2

11.6

1.49 (1.17, 1.89) b

G01

Gynecological antiinfectives and antiseptics

3.2

1.4

2.31 (1.24, 4.28) b

B

Blood and blood forming organs

16.2

14.5

1.12 (0.88, 1.42)

B01

Antithrombotic agents

13.3

12.0

1.10 (0.84, 1.45)

S

Sensory organs

8.8

11.4

0.77 (0.55, 1.08)

  1. aData are only shown for subcodes that were prescribed in > 10% of PKU patients or those that were significant vs the control population. ATC category totals may not add up because subcategories with < 5 patients in the PKU group have been excluded from the table, but may still count to the total for the ATC class of drug
  2. bATC codes that had a significant PR vs the control population
  3. One letter ATC codes (e.g. Dermatologicals, Cardiovascular system) are shown in bold
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172