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Table 3 Comorbidity profilea of adult PKU patients and matched controls in Germany in 2015

From: Clinical burden of illness in patients with phenylketonuria (PKU) and associated comorbidities - a retrospective study of German health insurance claims data

ICD-10-GM code Comorbidity PKU population (n = 377) Control population (n = 3,770) PR (95% CI)
% %
I10 Essential (primary) hypertension 38.7 36.2 1.07 (0.94, 1.22)
M54 Dorsalgia 35.3 30.3 1.16 (1.01, 1.34) b
E78 Disorders of lipoprotein metabolism and other lipidemias 33.7 25.1 1.34 (1.15, 1.56) b
Z12 Encounter for screening for malignant neoplasms 31.3 30.0 1.04 (0.89, 1.22)
H52 Disorders of refraction and accommodation 27.3 23.6 1.16 (0.97, 1.38)
Z30 Encounter for contraceptive management 22.5 21.2 1.06 (0.87, 1.30)
N89 Other noninflammatory disorders of vagina 21.8 18.0 1.21 (0.99, 1.48)
J06 Acute upper respiratory infections of multiple and unspecified sites 21.5 18.8 1.14 (0.93, 1.40)
Z01 Encounter for other specified exam without complaint, suspected or reported dx 20.7 14.0 1.47 (1.19, 1.82) b
F32 Major depressive disorder, single episode 16.2 13.3 1.22 (0.95, 1.55)
Z00 Encounter for general exam without complaint, suspected or reported dx 15.9 14.4 1.11 (0.87, 1.42)
E66 Overweight and obesity 15.9 11.2 1.43 (1.11, 1.83) b
I25 Chronic ischemic heart disease 15.7 9.0 1.74 (1.35, 2.25) b
F45 Somatoform disorders 15.4 12.1 1.27 (0.98, 1.63)
E11 Type 2 diabetes mellitus 14.9 11.6 1.28 (0.99, 1.66)
Z25 Need for immunization against other single viral diseases 14.3 13.1 1.09 (0.84, 1.42)
M53 Other and unspecified dorsopathies, not elsewhere classified 14.3 10.2 1.40 (1.08, 1.83) b
E04 Other nontoxic goiter 14.1 10.8 1.30 (1.00, 1.69)
M47 Spondylosis 13.8 12.2 1.13 (0.86, 1.47)
R10 Abdominal and pelvic pain 13.3 11.4 1.17 (0.89, 1.53)
M17 Osteoarthritis of knee 13.3 10.1 1.31 (1.00, 1.73)
N39 Other disorders of urinary system 13.0 9.4 1.38 (1.04, 1.82) b
K29 Gastritis and duodenitis 12.7 9.7 1.32 (0.99, 1.75)
N95 Menopausal and other perimenopausal disorders 12.5 8.6 1.46 (1.09, 1.94) b
J45 Asthma 11.9 7.0 1.70 (1.26, 2.29) b
D22 Melanocytic nevi 11.7 9.2 1.28 (0.95, 1.71)
E03 Other hypothyroidism 11.7 9.5 1.23 (0.92, 1.66)
J30 Vasomotor and allergic rhinitis 11.7 8.8 1.32 (0.98, 1.78)
R42 Dizziness and giddiness 11.1 6.0 1.84 (1.35, 2.52) b
F43 Reaction to severe stress, and adjustment disorders 10.9 7.0 1.56 (1.15, 2.14) b
E14 Unspecified diabetes mellitus 10.9 6.4 1.69 (1.23, 2.31) b
A09 Infectious gastroenteritis and colitis, unspecified 10.6 6.3 1.69 (1.23, 2.33) b
M79 Other and unspecified soft tissue disorders, not elsewhere classified 10.6 7.2 1.48 (1.08, 2.03) b
L30 Other and unspecified dermatitis 10.6 7.3 1.44 (1.05, 1.98) b
L30 Personal history of medical treatment 10.6 7.7 1.38 (1.01, 1.89) b
Q66 Congenital deformities of feet 10.3 8.0 1.29 (0.94, 1.77)
I83 Varicose veins of lower extremities 10.3 8.8 1.18 (0.86, 1.62)
E79 Disorders of purine and pyrimidine metabolism 10.1 6.8 1.49 (1.08, 2.06) b
T78 Adverse events, not elsewhere classified 10.1 5.9 1.71 (1.23, 2.37) b
  1. aOnly comorbidities present in > 10% of PKU patients are shown; a full listing of the top 50 comorbidities is provided in Additional file 1: Table S3
  2. bComorbidities that had a significant PR vs the control population