Table 3 Comorbidity profilea of adult PKU patients and matched controls in Germany in 2015
ICD-10-GM code | Comorbidity | PKU population (n = 377) | Control population (n = 3,770) | PR (95% CI) |
|---|---|---|---|---|
% | % | |||
I10 | Essential (primary) hypertension | 38.7 | 36.2 | 1.07 (0.94, 1.22) |
M54 | Dorsalgia | 35.3 | 30.3 | 1.16 (1.01, 1.34) b |
E78 | Disorders of lipoprotein metabolism and other lipidemias | 33.7 | 25.1 | 1.34 (1.15, 1.56) b |
Z12 | Encounter for screening for malignant neoplasms | 31.3 | 30.0 | 1.04 (0.89, 1.22) |
H52 | Disorders of refraction and accommodation | 27.3 | 23.6 | 1.16 (0.97, 1.38) |
Z30 | Encounter for contraceptive management | 22.5 | 21.2 | 1.06 (0.87, 1.30) |
N89 | Other noninflammatory disorders of vagina | 21.8 | 18.0 | 1.21 (0.99, 1.48) |
J06 | Acute upper respiratory infections of multiple and unspecified sites | 21.5 | 18.8 | 1.14 (0.93, 1.40) |
Z01 | Encounter for other specified exam without complaint, suspected or reported dx | 20.7 | 14.0 | 1.47 (1.19, 1.82) b |
F32 | Major depressive disorder, single episode | 16.2 | 13.3 | 1.22 (0.95, 1.55) |
Z00 | Encounter for general exam without complaint, suspected or reported dx | 15.9 | 14.4 | 1.11 (0.87, 1.42) |
E66 | Overweight and obesity | 15.9 | 11.2 | 1.43 (1.11, 1.83) b |
I25 | Chronic ischemic heart disease | 15.7 | 9.0 | 1.74 (1.35, 2.25) b |
F45 | Somatoform disorders | 15.4 | 12.1 | 1.27 (0.98, 1.63) |
E11 | Type 2 diabetes mellitus | 14.9 | 11.6 | 1.28 (0.99, 1.66) |
Z25 | Need for immunization against other single viral diseases | 14.3 | 13.1 | 1.09 (0.84, 1.42) |
M53 | Other and unspecified dorsopathies, not elsewhere classified | 14.3 | 10.2 | 1.40 (1.08, 1.83) b |
E04 | Other nontoxic goiter | 14.1 | 10.8 | 1.30 (1.00, 1.69) |
M47 | Spondylosis | 13.8 | 12.2 | 1.13 (0.86, 1.47) |
R10 | Abdominal and pelvic pain | 13.3 | 11.4 | 1.17 (0.89, 1.53) |
M17 | Osteoarthritis of knee | 13.3 | 10.1 | 1.31 (1.00, 1.73) |
N39 | Other disorders of urinary system | 13.0 | 9.4 | 1.38 (1.04, 1.82) b |
K29 | Gastritis and duodenitis | 12.7 | 9.7 | 1.32 (0.99, 1.75) |
N95 | Menopausal and other perimenopausal disorders | 12.5 | 8.6 | 1.46 (1.09, 1.94) b |
J45 | Asthma | 11.9 | 7.0 | 1.70 (1.26, 2.29) b |
D22 | Melanocytic nevi | 11.7 | 9.2 | 1.28 (0.95, 1.71) |
E03 | Other hypothyroidism | 11.7 | 9.5 | 1.23 (0.92, 1.66) |
J30 | Vasomotor and allergic rhinitis | 11.7 | 8.8 | 1.32 (0.98, 1.78) |
R42 | Dizziness and giddiness | 11.1 | 6.0 | 1.84 (1.35, 2.52) b |
F43 | Reaction to severe stress, and adjustment disorders | 10.9 | 7.0 | 1.56 (1.15, 2.14) b |
E14 | Unspecified diabetes mellitus | 10.9 | 6.4 | 1.69 (1.23, 2.31) b |
A09 | Infectious gastroenteritis and colitis, unspecified | 10.6 | 6.3 | 1.69 (1.23, 2.33) b |
M79 | Other and unspecified soft tissue disorders, not elsewhere classified | 10.6 | 7.2 | 1.48 (1.08, 2.03) b |
L30 | Other and unspecified dermatitis | 10.6 | 7.3 | 1.44 (1.05, 1.98) b |
L30 | Personal history of medical treatment | 10.6 | 7.7 | 1.38 (1.01, 1.89) b |
Q66 | Congenital deformities of feet | 10.3 | 8.0 | 1.29 (0.94, 1.77) |
I83 | Varicose veins of lower extremities | 10.3 | 8.8 | 1.18 (0.86, 1.62) |
E79 | Disorders of purine and pyrimidine metabolism | 10.1 | 6.8 | 1.49 (1.08, 2.06) b |
T78 | Adverse events, not elsewhere classified | 10.1 | 5.9 | 1.71 (1.23, 2.37) b |