Skip to main content

Table 1 Baseline characteristics of patients with unexplained conduction disorders and who underwent pacemaker implantation screened for AFD stratified by sex

From: Negative screening of Fabry disease in patients with conduction disorders requiring a pacemaker

  Total (n = 188) Males (n = 124) Females (n = 64)
Age at pacemaker implantation, years 63 ± 9 64 ± 7 62 ± 8
Medical history of neuropathy, n (%) 5 (3) 4 (3) 1(2)
Medical history of renal impairment, n (%) 24 (13) 20 (16) 4 (6)
Medical history of stroke, n (%) 24 (13) 19 (15) 5 (8)
Family history of SCD, n (%) 14 (7) 8 (7) 6 (9)
Family history of HCM, n (%) 2 (1) 1 (1) 1 (2)
Family history PMI, n (%) 27 (14) 18 (15) 9 (14)
Syncope, n (%) 73 (39) 45 (36) 28 (44)
Serum creatinine (mg/dl) 1.03 ± 0.46 1.08 ± 0.44 0.94 ± 0.49
PR interval, ms 189 ± 0.44 191 ± 57 186 ± 443
QRS interval, ms 116 ± 28 120 ± 27 109 ± 286
LVH in ECG, n (%) 40 (21) 32 (26) 8 (13)
Interventricular septum, mm 12 ± 3 12 ± 3 11 ± 3
LVEF, n (%) 60 ± 10 59 ± 11 63 ± 8
α-Gal activity, μmol/L/h 3.8 ± 1.7 3.9 ± 1.7 3.6 ± 1.6
  1. α-Gal A α-galactosidase A, HCM hypertrophic cardiomyopathy, LVH left ventricular hypertrophy, LVEF left ventricular ejection fraction, PMI pacemaker insertion, SCD sudden cardiac death