Table 3 MCDA Core Model (criteria appraised quantitatively) and MCDA Contextual Tool (criteria appraised qualitatively)
MCDA Core Model | |
Domains | Criteria |
Disease Impact | Disease severity |
Unmet needs | |
Comparative outcomes of orphan drugs | Improvement of efficacy/effectiveness |
Improvement of safety/ tolerability | |
Improvement of patient perceived health/PRO | |
Type of therapeutic benefit | |
Economic consequences of intervention | Annual patient cost of treatment |
Other medical costs | |
Knowledge about intervention | Quality of evidence |
Expert consensus/clinical practice guidelines | |
MCDA Contextual Tool | |
Domains | Criteria |
Normative contextual criteria | Population priorities and access (principle of equity) |
Common goal and specific interests | |
Feasibility contextual criteria | System capacity and appropriate use of orphan drugs |
Opportunity costs and affordability (budget impact) | |